Xuehai Liang

Argenica Therapeutics Ltd

United States

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Articles (10)

Year:

2025

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Collaborators (6)

Andrew Marshall

University of Western Australia

AUSTRALIA

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Mihwa Lee

La Trobe University

AUSTRALIA

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Gavin J. Knott

Lab Head

MONASH UNIVERSITY

AUSTRALIA

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Evelyne Deplazes

Senior Lecturer (Biochemistry)

University of Queensland

AUSTRALIA

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Adam Pollak

UNITED STATES

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Daniel M Passon

Head

Targenomix

GERMANY

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Xuehai Liang

Research Interests

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Articles (10)

Antisense oligonucleotide-mediated upregulation of Jag1 ameliorates liver disease phenotypes in a mouse model of Alagille syndrome

Insights into innate immune activation via PS-ASO-protein-TLR9 interactions.

Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1

RNA modifications can affect RNase H1-mediated PS-ASO activity

Perinuclear positioning of endosomes can affect PS-ASO activities

Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs

Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins

Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs

Antisense technology: A review

Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity

Collaborators (6)

Andrew Marshall

Mihwa Lee

Gavin J. Knott

Evelyne Deplazes

Adam Pollak

Daniel M Passon

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