Yann Sterckx

Professor

University of Antwerp

Belgium

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Yann Sterckx is a Professor at the University of Antwerp, Belgium. His research focuses on biophysical analysis and molecular modeling, particularly in the context of infectious diseases caused by protozoan parasites such as Leishmania and Plasmodium. Recent contributions include studies on protein conformational changes and allosteric inhibition in trypanosomatid pyruvate kinases. He is also involved in the discovery and development of therapeutic leads for diseases like African trypanosomiasis.

Yann Sterckx

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Articles (24)

Biophysical analysis of an oligomerization-attenuated variant of the Leishmania donovani dynamin-1-like protein

Evidence for a model of conformational change by the Plasmodium falciparum circumsporozoite protein during sporozoite development in the mosquito host through the use of camelid single-domain antibodies

Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

An Interdisciplinary Approach Provides Insights into the Pronounced Selectivity of Compound 42 for DPP9

Human Transmembrane Serine Protease 2 (TMPRSS2) on Human Seminal Fluid Extracellular Vesicles Is Proteolytically Active

Discovery and Development of an Advanced Lead for the Treatment of African Trypanosomiasis

Long-term hematopoietic stem cells trigger quiescence in Leishmania parasites.

Beyond the VSG layer: Exploring the role of intrinsic disorder in the invariant surface glycoproteins of African trypanosomes.

A high-throughput target-based screening approach for the identification and assessment of <i>Mycobacterium tuberculosis</i> mycothione reductase inhibitors.

Biophysical analysis of the membrane-proximal Venus Flytrap domain of ESAG4 receptor-like adenylate cyclase from Trypanosoma brucei

Mass spectrometry-complemented molecular modeling predicts the interaction interface for a camelid single-domain antibody targeting the Plasmodium falciparum circumsporozoite protein’s C-terminal domain

Evolutionary conservation of the structure and function of meiotic Rec114−Mei4 and Mer2 complexes

Biophysical characterization of the Plasmodium falciparum circumsporozoite protein's N-terminal domain.

A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers

Genomic and Phenotypic Characterization of Experimentally Selected Resistant Leishmania donovani Reveals a Role for Dynamin-1-Like Protein in the Mechanism of Resistance to a Novel Antileishmanial Compound

Retrospective in silico mutation profiling of SARS-CoV-2 structural proteins circulating in Uganda by July 2021

Immunogenicity Risk Profile of Nanobodies

The History of Anti-Trypanosome Vaccine Development Shows That Highly Immunogenic and Exposed Pathogen-Derived Antigens Are Not Necessarily Good Target Candidates: Enolase and ISG75 as Examples

Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins

An Unbiased Immunization Strategy Results in the Identification of Enolase as a Potential Marker for Nanobody-Based Detection of Trypanosoma evansi

Experimental Strategies to Explore Drug Action and Resistance in Kinetoplastid Parasites

Development of a recombinase polymerase amplification lateral flow assay for the detection of active Trypanosoma evansi infections

Structural and kinetic characterisation of Trypanosoma congolense pyruvate kinase

Identification of Nanobodies against the Acute Myeloid Leukemia Marker CD33

Collaborators (16)

ZENG LI

stefan magez

Alexander Volkov

Catarina Xavier

Tony Lahoutte

Vicky Caveliers

Pieter Van Wielendaele

Ahmet Krasniqi

Yvon Elkrim

Peter Tompa

Benoit Stijlemans

Remus Dame

Hideo Imamura

Corentin Claeys Bouuaert

Gabriele Giachin

Ben Caljon

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