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Yasuhiro Kosuge

Nihon University

Japan

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Research Interests

Neurology

20%

Pharmacology

80%

Neuropharmacology

60%

Oxidative Stress

50%

Neuroprotection

40%

Neurodegenerative Disease

30%

Motor Neuron

30%

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Articles14

Miyako <i>Bidens pilosa</i> Extract Ameliorates Allodynia and Suppresses Spinal Microglial Activation in Mice with Partial Sciatic Nerve Ligation

Year:

2025

Therapeutic Efficacy of Intranasal N-Acetyl-L-Cysteine with Cell-Penetrating Peptide-Modified Polymer Micelles on Neuropathic Pain in Partial Sciatic Nerve Ligation Mice

Year:

2025

MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons

Year:

2024

Anti-Inflammatory Effects of Miyako Bidens pilosa in a Mouse Model of Amyotrophic Lateral Sclerosis and Lipopolysaccharide-Stimulated BV-2 Microglia

Year:

2023

Update on the pathological roles of prostaglandin E2 in neurodegeneration in amyotrophic lateral sclerosis

Year:

2023

Utility of a Novel Micro-Spraying Device for Intranasal Administration of Drug Solutions to Mice

Year:

2023

Intranasal Administration of N-acetyl-L-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

Year:

2022

Present State and Future Perspectives of Prostaglandins as a Differentiation Factor in Motor Neurons

Year:

2022

Possible role of transcriptional regulation of 5-HT1A receptor in the midbrain on unadaptation to stress in mice

Year:

2022

A Metal-Free, Disulfide Oxidized Form of Superoxide Dismutase 1 as a Primary Misfolded Species with Prion-Like Properties in the Extracellular Environments Surrounding Motor Neuron-Like Cells

Year:

2021

Highly Efficient Conversion of Motor Neuron-Like NSC-34 Cells into Functional Motor Neurons by Prostaglandin E2

Year:

2020

The Molecular Mechanisms Underlying Prostaglandin D2-Induced Neuritogenesis in Motor Neuron-Like NSC-34 Cells

Year:

2020

Bidens pilosa Extract Administered after Symptom Onset Attenuates Glial Activation, Improves Motor Performance, and Prolongs Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

Year:

2020

Generation of Cellular Reactive Oxygen Species by Activation of the EP2 Receptor Contributes to Prostaglandin E2-Induced Cytotoxicity in Motor Neuron-Like NSC-34 Cells

Year:

2020

Collaborators4

Yoshihiko Nakatani

International University of Health and Welfare

JAPAN

Hiromu Kondo

Shizuoka University

JAPAN

Toyofumi Suzuki, Ph.D

Professor

Nihon University School of Pharmacy

JAPAN

Takanori Kanazawa

Associate Professor

Shizuoka University

JAPAN

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