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Yiming Xu

Research Assistant Professor

Virginia Commonwealth University

United States

Research Interests

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About

Dr. Yiming Xu is a Research Assistant Professor at Virginia Commonwealth University in the United States. His research primarily focuses on the characterization and development of NLRP3 inflammasome inhibitors, as well as novel PET imaging radiotracers. Recent articles authored by Dr. Xu explore the therapeutic significance of targeting NLRP3 in neurodegenerative diseases and lung injury, as well as the design of small-molecule inhibitors for various therapeutic applications.

Articles (12)

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2026

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2025

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2025

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2024

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2022

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2022

Collaborators (2)

Shijun Zhang

Virginia Commonwealth University

UNITED STATES

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Can Zhang

Associate Professor

Massachusetts General Hospital and Harvard Medical School

UNITED STATES

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Yiming Xu

Research Interests

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Articles (12)

Deconstructing the Master Switch: Advances in Direct NLRP3 Inhibition

Characterization of a novel PET radioligand for mitochondrial complex I in nonhuman primate.

Mechanistic Characterization of a Small Molecule as a Direct NLRP3 Inhibitor via Binding to the NACHT Domain.

Biological and therapeutic significance of targeting NLRP3 inflammasome in the brain and the current efforts to develop brain-penetrant inhibitors.

Functional Characterization of an Arylsulfonamide-Based Small-Molecule Inhibitor of the NLRP3 Inflammasome.

Characterization of a small molecule inhibitor of the NLRP3 inflammasome and its potential use for acute lung injury.

A patent review of NLRP3 inhibitors to treat autoimmune diseases

Design and Discovery of Novel NLRP3 Inhibitors and PET Imaging Radiotracers Based on a 1,2,3-Triazole-Bearing Scaffold.

Development of NLRP3 inhibitors for intervening in Alzheimer’s disease

Mechanistic Insights of Sulfonamide‐Based NLRP3 Inhibitors for the Treatment of Neurodegenerative Diseases

Development of sulfonamide-based NLRP3 inhibitors: Further modifications and optimization through structure-activity relationship studies

Novel matrinic acid derivatives bearing 2-anilinothiazole structure for non-small cell lung cancer treatment with improved Hsp90 targeting effect

Collaborators (2)

Shijun Zhang

Can Zhang

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