Yong Zhou

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Assistant Professor (tenure-track)

The University of Texas Health Science Center at Houston

United States

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Yong Zhou is an Assistant Professor (tenure-track) at the University of Texas Health Science Center at Houston, USA. His research focuses on KRAS lipid dynamics, cell signaling, and oncogenic Ras clustering, as evidenced by his recent publications exploring lipid landscape regulation and targeted interventions in pancreatic cancer. He is dedicated to advancing our understanding of RAS GTPases and their role in cellular processes and cancer mechanisms.

Recent Grants

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Phosphatidylserine acyl chain remodeling regulates KRAS spatial distribution and function on the plasma membrane.

Open Date: 2021-04-01

Close Date: 2025-03-01

Grant: Close

Effects of bile acids on MAPK signaling in cholestasis

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Close Date:

Articles (14)

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2025

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2025

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2024

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2024

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2021

Collaborators (11)

Ching On Wong

Assistant Professor

Rutgers University

UNITED STATES

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Carlito Lebrilla

Distinguished Professor

University of California, Davis

UNITED STATES

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Wenting Zhao

Assistant Professor

Nanyang Technological University (NTU)

SINGAPORE

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Ryan Insolera

Assistant Professor

Wayne State University School of Medicine

UNITED STATES

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Junchen Liu

Assistant Professor

The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School

UNITED STATES

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Ransome van der Hoeven

Associate Professor

The University of Texas Health Science Center at Houston

UNITED STATES

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Jeffrey Chang

The University of Texas Health Science Center at Houston

UNITED STATES

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Ransome van der Hoeven

Associate Professor

The University of Iowa

UNITED STATES

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Tom Grossmann

University of Amsterdam

NETHERLANDS

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George G Rodney

Associate Professor

Baylor College of Medicine

UNITED STATES

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Alejandro Yeste Vázquez

University of Amsterdam

NETHERLANDS

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Yong Zhou

Research Interests

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About

Recent Grants

Articles (14)

Terraforming the KRAS lipid landscape

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

Identification of an H-Ras nanocluster disrupting peptide

RAS G-domains allosterically contribute to the recognition of lipid headgroups and acyl chains

RAS GTPases and Interleaflet Coupling in the Plasma Membrane

RAS nanoclusters are cell surface transducers that convert extracellular stimuli to intracellular signalling

Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids

UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting

Patterning of Oncogenic Ras Clustering in Live Cells Using Vertically Aligned Nanostructure Arrays

Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer

Lipid Profiles of RAS Nanoclusters Regulate RAS Function

RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains

Osimertinib-resistant NSCLC cells activate ERBB2 and YAP/TAZ and are killed by neratinib

Regulation of longevity by depolarization-induced activation of PLC-β–IP3R signaling in neurons

Collaborators (11)

Ching On Wong

Carlito Lebrilla

Wenting Zhao

Ryan Insolera

Junchen Liu

Ransome van der Hoeven

Jeffrey Chang

Ransome van der Hoeven

Tom Grossmann

George G Rodney

Alejandro Yeste Vázquez

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