Yoshiro Saito

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Tohoku University

Japan

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Professor Yoshiro Saito is a faculty member at Tohoku University in Japan. His research focuses on chronic kidney disease, hepatocellular carcinoma, and the role of selenoproteins in neurodegenerative diseases. Recent publications include studies on renal fibrosis, antioxidant mechanisms, and the effects of selenium on various health conditions. He is committed to advancing the understanding of metabolic remodeling and its implications for disease treatment.

Recent Grants

Grant: Close

Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolism

Open Date: 2020-04-01

Close Date: 2024-03-31

Grant: Close

Molecular mechanisms of disorder of pancreatic beta cells induced by excess selenoprotein P

Open Date: 2017-04-01

Close Date: 2020-03-31

Grant: Close

Selenium-transport mechanism of selenoprotein P

Open Date: 2013-04-01

Close Date: 2017-03-31

Articles (17)

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2025

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2024

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2024

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2024

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2021

Collaborators (7)

Shigeyuki Kon

Fukuyama University

JAPAN

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Ewa Jablonska

Nofer Institute of Occupational Medicine

POLAND

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Keiko Taguchi

Associate Professor

University of Tokyo

JAPAN

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Teresa Urbano

University of Modena and Reggio Emilia

ITALY

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Yasuomi Urano

Doshisha University

JAPAN

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Ryuichi Sakai

Professor

Kitasato University

JAPAN

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Ryouhei Tsutsumi

Junior Associate Professor

Kitasato University

JAPAN

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Yoshiro Saito

Research Interests

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About

Recent Grants

Articles (17)

Lactoferrin attenuates renal fibrosis and uremic sarcopenia in a mouse model of adenine-induced chronic kidney disease

NRF2-dependent suppression of selenoprotein P expression promotes intracellular selenium metabolic remodeling and upregulation of antioxidant selenoproteins in hepatocellular carcinoma

Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation

Differential associations between selenoprotein P and distal sensorimotor polyneuropathy in people with and without diabetes: KORA F4/FF4 study

Cholesterol is more readily oxidized than phospholipid linoleates in cell membranes to produce cholesterol hydroperoxides

Modifications of DJ-1 in which pI shifts to acidic in red blood cells a potential biomarker for Parkinson’s disease at early stages

Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2

Safety of selenium exposure and limitations of selenoprotein maximization: Molecular and epidemiologic perspectives

Selenoprotein P Concentrations in the Cerebrospinal Fluid and Serum of Individuals Affected by Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment and Alzheimer’s Dementia

Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation

Essential trace element selenium and redox regulation: its metabolism, physiological function, and related diseases

Redox-sensitive DJ-1 protein: an insight into physiological roles, secretion, and therapeutic target

Nephronectin influences EAE development by regulating the Th17/Treg balance via reactive oxygen species

Role of selenoprotein P expression in the function of pancreatic β cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation

Diverse cytoprotective actions of vitamin E isoforms- role as peroxyl radical scavengers and complementary functions with selenoproteins

Lipid peroxidation products as a mediator of toxicity and adaptive response – The regulatory role of selenoprotein and vitamin E

Identification of an endogenous long non-coding RNA that inhibits selenoprotein P translation- New regulatory mechanism of SeP translation

Collaborators (7)

Shigeyuki Kon

Ewa Jablonska

Keiko Taguchi

Teresa Urbano

Yasuomi Urano

Ryuichi Sakai

Ryouhei Tsutsumi

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