Yuki Yamaguchi

Professor

Tokyo Institute of Technology

Japan

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About

Yuki Yamaguchi is a Professor at the Tokyo Institute of Technology in Japan. His research areas focus on the regulation of transcription, mRNA splicing, and the molecular mechanisms underlying cell cycle and differentiation. Recent articles highlight his work on RNA polymerase II, the Integrator complex, and the role of ubiquitin ligase in therapeutic applications. He actively contributes to advancing understanding of genetic regulation and cellular processes through multi-omics approaches.

Articles (11)

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2025

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2025

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2024

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2023

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2022

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2022

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2022

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2021

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2020

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2020

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2020

Collaborators (8)

Nobuyuki Shimizu

Oita University

JAPAN

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Masahiko Okuda

Project Associate Professor

Yokohama National University

JAPAN

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Satoshi Fujii

Kyushu Institute of Technology

JAPAN

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Hiroshi Handa

Tokyo Medical and Dental University

JAPAN

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Takumi Ito

Associate Professor

Tokyo Medical and Dental University

JAPAN

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Tadasuke Tsukiyama

Hokkaido University

JAPAN

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Yoshifumi Nishimura

Yokohama National University

JAPAN

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Hiroshi Nishina

Professor

Tokyo Medical and Dental University

JAPAN

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Yuki Yamaguchi

Research Interests

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About

Articles (11)

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis

INTS15, A Subunit of the Integrator Complex, Plays a Key Regulatory Role in Cell Cycle and Differentiation

Multi-omics analysis using antibody-based in situ biotinylation technique suggests the mechanism of Cajal body formation

Integrator complex subunit 15 controls mRNA splicing and is critical for eye development

Three human RNA polymerases interact with TFIIH via a common RPB6 subunit.

The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies

Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders

Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology

ARID2 is a pomalidomide-dependent CRL4<sup>CRBN</sup> substrate in multiple myeloma cells

The role of Mediator and Little Elongation Complex in transcription termination

Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide

Collaborators (8)

Nobuyuki Shimizu

Masahiko Okuda

Satoshi Fujii

Hiroshi Handa

Takumi Ito

Tadasuke Tsukiyama

Yoshifumi Nishimura

Hiroshi Nishina

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