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Yukio Ago

Professor

Hiroshima University

Japan

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Research Interests

Behavioral Neuroscience

40%

Systems Neuroscience

30%

Neuropharmacology

90%

Neuroscience

30%

G Protein-coupled Receptor

30%

Psychobiology

20%

Neuropeptide

20%

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Recent Grants

Grant: Close

Neurochemical study for cognitive behavioral therapy in mouse models of neuropsychiatric and neurodevelopmental disorders

Open Date: 2016-04-01

Close Date: 2018-03-31

Grant: Close

Drug discovery research targeting the novel regulation of prefrontal dopaminergic system by the functional interaction between the sigma1 and serotonin1A receptors

Open Date: 2016-04-01

Close Date: 2019-03-31

Grant: Close

Drug discovery research targeting brain neurochemical signals responsible for induction of abnormal behaviors in mouse models of psychiatric disorders

Open Date: 2013-04-01

Close Date: 2016-03-31

Grant: Close

Study on pathophysiological roles of brain NO-NCX signal

Open Date: 2011-04-01

Close Date: 2014-03-31

Grant: Close

Neuropharmacological study on drug development targeting forbrain metabotropic glutamate 2/3 receptors

Open Date: 2011-01-01

Close Date: 2012-12-31

Yukio Ago

Professor

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Research Interests

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Recent Grants

Articles15

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

Nitrous oxide increases peripheral blood flow and decreases plasma adrenaline and noradrenaline concentrations in human volunteers: An in vivo nonrandomized clinical and in vitro chromaffin cell culture study

ALKBH8 contributes to neurological function through oxidative stress regulation

(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice

Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice

The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibody

AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S–S bond (Cys25−Cys192) formation of functional significance for VIPR2

Investigation of the Transport Pathways Associated with Enhanced Brain Delivery of Peptide Drugs by Intranasal Coadministration with Penetratin

The pivotal role of pituitary adenylate cyclase-activating polypeptide for lactate production and secretion in astrocytes during fear memory

Examination of dissolution ratio of β-carotene in water for practical application of β-carotene amorphous solid dispersion

Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders

Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZ <sup>WT/Q1038R</sup> mouse model of autism spectrum disorder

Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia

Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular Models

Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood–brain barrier permeability for drug delivery to the brain in a non-human primate

Collaborators8

Rei Yokoyama

Kazutake Tsujikawa

Hitoshi Hashimoto

Nobumasa Hino

Ryuichi Hirayama

Noriyasu Kamei

Satoshi Asano

Takanori Kanazawa

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