Yunpeng Bai

Purdue University

United States

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Articles (13)

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2025

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2024

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2020

Collaborators (8)

Wen Jiang

Professor

Purdue University

UNITED STATES

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Danny Huang

Professor of Cancer Structural Biology

University of Glasgow

UNITED KINGDOM

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W Andy Tao

Purdue University

UNITED STATES

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Huiping Liu

Associate Professor

Northwestern University

UNITED STATES

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James Ropa

Assistant Professor

Indiana University School of Medicine

UNITED STATES

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Lars Rönnstrand

Lund University

SWEDEN

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Sarah Croessmann

Research Assistant Professor

Vanderbilt University Medical Center

UNITED STATES

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Wenjie Cai

Associate Professor in Tourism

UNITED KINGDOM

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Yunpeng Bai

Research Interests

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Articles (13)

The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor

PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation

Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers

Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models

PRL2 inhibition elevates PTEN protein and ameliorates progression of Acute Myeloid Leukemia

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.

Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity

Discovery of a selective TC-PTP degrader for cancer immunotherapy

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.

Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells.

Systemic inhibition of PTPN22 augments anticancer immunity.

Cryo-Electron Microscopy Structures of VCP/p97 Reveal a New Mechanism of Oligomerization Regulation

Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.

Collaborators (8)

Wen Jiang

Danny Huang

W Andy Tao

Huiping Liu

James Ropa

Lars Rönnstrand

Sarah Croessmann

Wenjie Cai

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