Yusuke Takeshima

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Specially Appointed Assistant Professor

Osaka University

Japan

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About

Yusuke Takeshima is a Specially Appointed Assistant Professor at Osaka University, Japan. His research interests encompass the fields of immunology and genetics, with a focus on the role of immune cells in various diseases, including rheumatoid arthritis and systemic lupus erythematosus. He has recently contributed to advancements in understanding genetic factors in immune responses and disease mechanisms through studies utilizing CRISPR technology and transcriptome profiling.

Recent Grants

Grant: Close

Elucidation of Signaling Mechanisms Involved in Human Regulatory T Cell Differentiation by Multi-omics Analysis

Open Date: 2022-04-01

Close Date: 2024-03-31

Grant: Close

Elucidation of immune and allergic disease dynamics by integrative sequencing analysis

Open Date: 2022-04-01

Close Date: 2025-03-31

Articles (13)

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2025

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2025

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2025

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

Collaborators (13)

Yasuo Nagafuchi

University of Tokyo

JAPAN

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K Fujio

University of Tokyo

JAPAN

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MITSUHIRO YAMADA

Senior Assistant Professor

Assistant Professor

Osaka University

JAPAN

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Yusuke Takeshima

Research Interests

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About

Recent Grants

Articles (13)

Author Correction: Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3

Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3

Methylglyoxal compromises callus mineralization and impairs fracture healing through suppression of osteoblast terminal differentiation

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance.

Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of Myositis-Specific Antibody-Positive Inflammatory Myopathies.

Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis

Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells

Transcriptome analysis of immune cells from Behçet's syndrome patients: the importance of IL-17-producing cells and antigen-presenting cells in the pathogenesis of Behçet's syndrome.

Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus.

Dysregulation of the gene signature of effector regulatory T cells in the early phase of systemic sclerosis

Distinct transcriptome architectures underlying lupus establishment and exacerbation

Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells

Collaborators (13)

Yasuo Nagafuchi

K Fujio

MITSUHIRO YAMADA

Kiminori Yukata

James Wing

Shuji Sumitomo

Hiromu Tanaka

Tomomi Takano

Tomohisa Okamura

Takayoshi Morita

Yu-Chen Liu

Toshihisa Anzai

Shuhei Sakakibara

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