Yusuke Takezawa

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Assistant professor

University of Tokyo

Japan

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About

Yusuke Takezawa is an Assistant Professor at The University of Tokyo, Japan. His research focuses on the design and synthesis of metal-responsive DNA materials, including functional DNA supramolecules and enzymatically synthesized oligonucleotides. Recent publications highlight advancements in metal-mediated DNA strand displacement and the development of DNAzymes with unique base-pairing capabilities.

Recent Grants

Grant: Close

酵素反応を駆使した金属イオン応答性DNA超分子の創製

Open Date: 2018-04-01

Close Date: 2021-03-31

Grant: Close

水素結合および金属配位結合により対合する人工塩基対を用いたＤＮＡ鎖交換反応の開発

Open Date: 2016-04-01

Close Date: 2018-03-31

Grant: Close

Construction of PCR-like amplification system of artificial metallo-DNAs

Open Date: 2011-04-28

Close Date: 2015-03-31

Articles (14)

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2024

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2024

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2023

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2023

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2023

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2022

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2021

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2021

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2021

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2021

Collaborators (2)

Kotaro Nishiyama

Assistant Professor

Meiji University

JAPAN

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Takahiro Nakama

Project Assistant Professor

University of Tokyo

JAPAN

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Yusuke Takezawa

Research Interests

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About

Recent Grants

Articles (14)

Metal-dependent activity control of a compact-sized 8–17 DNAzyme based on metal-mediated unnatural base pairing

Rational design of metal-responsive functional DNA supramolecules

Enzymatic synthesis of ligand-bearing oligonucleotides for the development of metal-responsive DNA materials

Ligase-mediated synthesis of CuII-responsive allosteric DNAzyme with bifacial 5-carboxyuracil nucleobases

Metal-mediated DNA strand displacement and molecular device operations based on base-pair switching of 5-hydroxyuracil nucleobases

CuII-mediated DNA base pairing of a triazole-4-carboxylate nucleoside prepared by click chemistry

CuII-mediated stabilisation of DNA duplexes bearing consecutive ethenoadenine lesions and its application to a metal-responsive DNAzyme

Metal-dependent base pairing of bifacial iminodiacetic acid-modified uracil bases for switching DNA hybridization partner

Phenanthroline-modified DNA three-way junction structures stabilized by interstrand 3 : 1 metal complexation

Metal-mediated DNA base pairing of easily prepared 2-oxo-imidazole-4-carboxylate nucleotides

Bipyridine‐Modified DNA Three‐Way Junctions with Amide linkers: Metal‐Dependent Structure Induction and Self‐Sorting

Front Cover: Bipyridine‐Modified DNA Three‐Way Junctions with Amide linkers: Metal‐Dependent Structure Induction and Self‐Sorting (Chem. Eur. J. 67/2021)

Metal-responsive reversible binding of triplex-forming oligonucleotides with 5-hydroxyuracil nucleobases

Site-specific polymerase incorporation of consecutive ligand-containing nucleotides for multiple metal-mediated base pairing

Collaborators (2)

Kotaro Nishiyama

Takahiro Nakama

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