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Zarazuela Zolkipli-Cunningham

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Attending Physician and Clinical Research Director, Mitochondrial Medicine Frontier Program

Children's Hospital of Philadelphia

United States

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Professors in United States

Recent Grants

Grant: Open

Addressing the Research Gap in Mitochondrial Myopathy with Validated Outcome Measures and Natural History

Open Date: 2024-08-01

Close Date: 2029-07-01

Grant: Close

Development and Clinical Validation of Noninvasive Diagnostics for Mitochondrial Disease

Open Date: 2022-10-01

Close Date: 2026-09-01

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Collaborators (18)

Eugenio Mercuri

Professor of Pediatric Neurology

Università Cattolica del Sacro Cuore

ITALY

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Jacqueline Montes

Associate Professor

Columbia University Irving Medical Center

UNITED STATES

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James Peterson

MS, LCGC

Children's Hospital of Philadelphia

UNITED STATES

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Kristin Krosschell

Professor

Northwestern University

UNITED STATES

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Jose Adams

Chief of Neonatology

Mount Sinai Hospital

UNITED STATES

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Deanne Taylor

Research Associate Professor

University of Pennsylvania

UNITED STATES

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Michelle Farrar

Senior Lecturer, Paediatric Neurology

University of New South Wales

AUSTRALIA

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Rui Xiao

University of Pennsylvania

UNITED STATES

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Richard Finkel

Director, Center for Experimental Neurotherapeutics

St. Jude Children's Research Hospital

UNITED STATES

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Elise Townsend

Associate Professor

MGH Institute of Health Professions

UNITED STATES

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Douglas Wallace

Professor

University of Pennsylvania

UNITED STATES

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Anna Capasso

Agostino Gemelli University Polyclinic

ITALY

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Marni Falk

Assistant Professor

University of Pennsylvania

UNITED STATES

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John Day

Professor of Neurology and Pediatrics

Stanford University

UNITED STATES

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Tina Duong

Stanford University

UNITED STATES

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Michael McDermott

Professor

University of Rochester Medical Center

UNITED STATES

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Mark G. Allen

University of Pennsylvania

UNITED STATES

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Lishuang Shen

Clinical Staff Scientist, Sr. Bioinformatics Scientist

Children's Hospital of Los Angeles

UNITED STATES

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Zarazuela Zolkipli-Cunningham

Research Interests

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Recent Grants

Articles (20)

Loss of ambulation in SMA III at the time of disease-modifying treatments: an international study

Navigating new motor function trajectories: Consensus recommendations for assessment in the era of newborn screening and early treatment in SMA

Quantitative assessment of efficacy and evaluation of feasibility of exercise training protocols in adult and pediatric primary mitochondrial disease.

Endothelial–mitochondrial coupling in mitochondrial disease: A systematic review and quantitative synthesis of vascular, biochemical, and oxidative bioenergetic dysfunction

Advances in diagnosis of mitochondrial dysfunction and primary mitochondrial disease

MSeqDR PMD-VR: An Expert-Curated Virtual Registry of 11,000 Mitochondrial Disease Cases Established Through Literature Mining and Generative AI Augmentation

Use of nucleoside therapy for mitochondrial DNA depletion/deletion syndrome (MDDS).

A Miniaturized Enzymatic Lactate Sensor for Continuous Monitoring in Oxygen-Depleted Tissue Microenvironments

Evaluation of muscle microvascular perfusion in primary mitochondrial disease by contrast-enhanced ultrasound: Feasibility study

Interim analysis of an international multi-site prospective natural history study evaluating the clinical presentation and progression of Leigh syndrome spectrum disorders

Optical Monitoring of Calf Muscle Blood Flow and Oxygenation during Passive Simulated Jogging in Patients with Mitochondrial Disease

Progress and perspectives in primary mitochondrial myopathy: Highlights from the 2025 mitochondrial medicine masterclass with a focus on TK2 deficiency

Spinal Muscular Atrophy Functional Composite Score Revised (SMA-FCR) in Untreated and Nusinersen-Treated Patient Cohorts

The profound implications of mitochondrial myopathy on activities of daily living: an observational qualitative study of standardized structured and semi-structured patient interviews

Interpreting the clinical significance of multiple large-scale mitochondrial DNA deletions (MLSMD) in skeletal muscle tissue in the diagnostic evaluation of primary mitochondrial disease.

Microfabricated electrochemical oxygen sensors with hydrogel electrolytes for in vivo applications

Longitudinal Assessment of 4-Year HFMSE Changes in SMA II and III Patients Treated With Nusinersen

Bulbar function in spinal muscular atrophy (SMA): State of art and new challenges. 21st July 2023, Rome, Italy

Beyond Contractures in Spinal Muscular Atrophy: Identifying Lower-Limb Joint Hypermobility

MMFP-Tableau: enabling precision mitochondrial medicine through integration, visualization, and analytics of clinical and research health system electronic data

Collaborators (18)

Eugenio Mercuri

Jacqueline Montes

James Peterson

Kristin Krosschell

Jose Adams

Deanne Taylor

Michelle Farrar

Rui Xiao

Richard Finkel

Elise Townsend

Douglas Wallace

Anna Capasso

Marni Falk

John Day

Tina Duong

Michael McDermott

Mark G. Allen

Lishuang Shen

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