Zhanjun Hou

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Associated Professor (Research)

Wayne State University

United States

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About

Dr. Zhanjun Hou is an Associate Professor (Research) at Wayne State University in the United States. His research focuses on one-carbon metabolism, targeted therapies in cancer treatment, and the structural characterization of antifolate inhibitors. Recent publications include studies on Ewing Sarcoma growth suppression, Wnt responsiveness in ovarian cancer, and the role of folate transporters in anticancer drug development.

Recent Grants

Grant: Close

Biology of major folate transporters and STING signaling in cancer

Open Date: 2022-04-05

Close Date: 2024-03-31

Grant: Close

Therapeutic Targeting Mitochondrial C1 Metabolism

Open Date: 2021-01-01

Close Date: 2025-12-31

Grant: Close

稻瘟菌诱导性水稻脂氧酶基因的启动子克隆及功能区解析

Open Date: 2001-01-01

Close Date: 2003-12-31

Grant: Close

Molecular Regulation of Folate and Antifolate Transport

Open Date: 1993-02-12

Close Date: 2025-06-30

Articles (14)

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2025

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2022

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2021

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2021

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2020

Collaborators (5)

Shrey Patel

Albert Einstein College of Medicine

UNITED STATES

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Heather Gibson

Assistant Professor

Wayne State University

UNITED STATES

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Rouba Ali-Fehmi

Professor, Breast Pathology, Gynecologic Pathology

University of Michigan

UNITED STATES

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Manasa Punaha Ravindra

King's College London

UNITED KINGDOM

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Aleem Gangjee

Duquesne University

UNITED STATES

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Zhanjun Hou

Research Interests

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About

Recent Grants

Articles (14)

One-Carbon Metabolism Inhibition Depletes Purines and Results in Profound and Prolonged Ewing Sarcoma Growth Suppression

BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer

Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport

Pattern Analysis of Organellar Maps for Interpretation of Proteomic Data

Biology and therapeutic applications of the proton-coupled folate transporter

Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer

Folate transporter offers clues for anticancer drugs

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

The evolving biology of the proton-coupled folate transporter: New insights into regulation, structure, and mechanism

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism

Collaborators (5)

Shrey Patel

Heather Gibson

Rouba Ali-Fehmi

Manasa Punaha Ravindra

Aleem Gangjee

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