Zhe Han

Professor

University of Maryland

United States

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Professor Zhe Han is a faculty member at the University of Maryland Baltimore, USA. His research focuses on HIV-related kidney diseases, cardiac signaling in Drosophila, and the physiological roles of nephrocytes. He has contributed significantly to understanding complex interactions in cellular and molecular biology, particularly in the contexts of viral infections and neurodevelopmental disorders.

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Western University of Health Sciences

UNITED STATES

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Zhe Han

Research Interests

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About

Articles (23)

HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in HIV-related kidney diseases

AlkTango reveals a role for Jeb/Alk signaling in the Drosophila heart

Piezo, Nephrocyte Function, and Slit Diaphragm Maintenance in Drosophila

SARS-CoV-2 ORF7a activates the endothelium to release von Willebrand factor that promotes thrombosis

SLK is mutated in individuals with a neurodevelopmental disorder

Drosophila Nephrocyte as a Model for Studying Glomerular Basement Membrane Physiology

Actin Cytoskeleton and Integrin Components Are Interdependent for Slit Diaphragm Maintenance in Drosophila Nephrocytes

Dysfunction of Mitochondrial Dynamics Induces Endocytosis Defect and Cell Damage in Drosophila Nephrocytes

Promoting mitochondrial dynamics by inhibiting the PINK1–PRKN pathway to relieve diabetic nephropathy

SARS-CoV-2 Nsp6-Omicron causes less damage to the Drosophila heart and mouse cardiomyocytes than ancestral Nsp6

Distinct roles of COMPASS subunits to Drosophila heart development

Single-cell profiling of the developing embryonic heart in Drosophila

APOL1-G2 accelerates nephrocyte cell death by inhibiting the autophagy pathway

A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes

Pharmacological or genetic inhibition of hypoxia signaling attenuates oncogenic RAS-induced cancer phenotypes

Lpt, trr, and Hcf regulate histone mono- and dimethylation that are essential for Drosophila heart development

Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment

Understanding individual SARS-CoV-2 proteins for targeted drug development against COVID-19

Understanding Individual SARS-CoV-2 Proteins for Targeted Drug Development against COVID-19

Drosophila, a powerful model to study virus-host interactions and pathogenicity in the fight against SARS-CoV-2.

Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes.

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.

Collaborators (5)

Weiwei Dang

Xiaohu Huang

Junyi Zhu

Hangnoh Lee

Brian Wasko

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