Ziqiang Guan

Research Professor

Duke University

United States

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Dr. Ziqiang Guan is a Research Professor at Duke University, USA. His research areas encompass lipid biosynthesis, pathogen virulence mechanisms, and neurosteroid regulation, as reflected in his recent publications. His work includes investigations into lipid formation pathways in planctomycetes and the structural characterization of essential proteins from Mycobacterium tuberculosis and fungal pathogens. Dr. Guan employs machine learning to enhance lipid discovery and to characterize bacterial enzymes critical for pathogen survival.

Articles (18)

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2025

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (7)

Nevan Krogan

University of California, San Francisco

UNITED STATES

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Meghna Gupta

Assistant Professor

Oregon Health & Science University

UNITED STATES

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Ye Zhou

Duke University

UNITED STATES

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Nitesh Khandelwal

Research Assistant Professor

Oregon Health & Science University

UNITED STATES

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Florent Sebbane

FRANCE

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John R. Perfect

Duke University School of Medicine

UNITED STATES

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Kelli L. Palmer

University of Texas at Dallas

UNITED STATES

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Ziqiang Guan

Research Interests

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About

Articles (18)

Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A

A biosynthetic pathway for ornithine lipid formation dependent on a GH3 (Gretchen Hagen 3)-like enzyme in planctomycetes

CpgD is a phosphoglycerate cytidylyltransferase required for ceramide diphosphoglycerate synthesis

Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3

Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans : A target for antifungals

Streptococcus agalactiae glycolipids promote virulence by thwarting immune cell clearance

Lipid discovery enabled by sequence statistics and machine learning

Lipid discovery enabled by sequence statistics and machine learning

Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens

Characterization of an evolutionarily distinct bacterial ceramide kinase from Caulobacter crescentus

Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13

Structural basis for inhibition and regulation of a chitin synthase from Candida albicans

Structural basis of NPR1 in activating plant immunity

Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague

Identification of a novel cationic glycolipid in Streptococcus agalactiae that contributes to brain entry and meningitis

Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing Yersinia pseudotuberculosis

Streptococcus pneumoniae, S. pyogenes and S. agalactiae membrane phospholipid remodelling in response to human serum

Critical Role of 3′-Downstream Region of pmrB in Polymyxin Resistance in Escherichia coli BL21(DE3)

Collaborators (7)

Nevan Krogan

Meghna Gupta

Ye Zhou

Nitesh Khandelwal

Florent Sebbane

John R. Perfect

Kelli L. Palmer

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