Ziying Yan

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Iowa State University

United States

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Recent Grants

Grant: Close

Mechanisms Underlying the Transduction Polarity of AAV in Polarized Human Airway Epithelium

Open Date: 2020-02-13

Close Date: 2022-01-31

Grant: Close

Gene Editing for Cystic Fibrosis Gene Therapy in Ferret Models

Open Date: 2019-07-01

Close Date: 2022-06-01

Grant: Close

Human bocavirus 1 (HBoV1) capsid entry and intracellular trafficking of polarized human airway epithelium

Open Date: 2018-05-11

Close Date: 2020-04-30

Articles (15)

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UNITED STATES

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Wei Zou

University of Michigan

UNITED STATES

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Bradley Rosen

Assistant Professor of Clinical Medicine, Pulmonary, and Critical Care

Indiana University Health

UNITED STATES

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Ziying Yan

Research Interests

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Recent Grants

Articles (15)

A Versatile Reporter Platform for Evaluating HDR- and NHEJ-Based Genome Editing in Airway Epithelial Cell Cultures Using an rAAV Vector

SARS‐CoV‐2 infection of polarized human airway epithelium induces necroptosis that causes airway epithelial barrier dysfunction

Transgenic ferret models define pulmonary ionocyte diversity and function

Identification of host essential factors for recombinant AAV transduction of the polarized human airway epithelium.

Inhibition of DNA-dependent protein kinase catalytic subunit boosts rAAV transduction of polarized human airway epithelium.

Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication.

In vivo genome editing shows promise for treating pulmonary diseases

Immunosuppression reduces rAAV2.5T neutralizing antibodies that limit efficacy following repeat dosing to ferret lungs.

Recombinant Adeno-Associated Virus-Mediated Editing of the G551D Cystic Fibrosis Transmembrane Conductance Regulator Mutation in Ferret Airway Basal Cells

The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway Epithelia

Establishment of a Recombinant AAV2/HBoV1 Vector Production System in Insect Cells

Long-Term Modeling of SARS-CoV-2 Infection of In Vitro Cultured Polarized Human Airway Epithelium

Detargeting Lentiviral-Mediated CFTR Expression in Airway Basal Cells Using miR-106b

Human Bocavirus 1 Infection of Well-Differentiated Human Airway Epithelium.

Viral Vectors, Animal Models, and Cellular Targets for Gene Therapy of Cystic Fibrosis Lung Disease.

Collaborators (9)

XIAOMING LIU

David Dick

Jianming Qiu

Thad Wadas

Kristen Wells

Guillermo Sergio Romano Ibarra

Susan E. Birket

Wei Zou

Bradley Rosen

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