Publisher
source

University of East Anglia

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PhD Studentship: A Hostile Niche: How Mutant Blood Stem Cells Damage Their Healthy Neighbours University of East Anglia in United Kingdom

Degree Level

PhD

Field of study

Cell Biology

Funding

Available

Deadline

Nov 30, 2026

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Country

United Kingdom

University

University of East Anglia

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Keywords

Cell Biology
Metabolism
Immunology
Hematology
Biology
Gene Expression
Stem Cell Biology
Aging
Medical Science
Rna-seq
Bioscience

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About this position

[4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD studentship; tuition fees paid directly to the University; stipend £21,805 per year (2026/27); Research Training Support Grant £5,000 per year.]

PhD Studentship at the University of East Anglia on A Hostile Niche: How Mutant Blood Stem Cells Damage Their Healthy Neighbours.

This project investigates how age-related mutations in blood stem cells may do more than simply give mutant cells a growth advantage: the work suggests they can reshape the bone marrow environment and alter the behaviour of nearby healthy stem cells. The research aims to identify which blood cell populations are affected and to determine the gene-expression and metabolic changes underlying this hostile niche, with the broader goal of understanding whether these interactions accelerate ageing of normal blood cells.

The successful candidate will develop a wide range of transferable research skills, including flow cytometry across the blood hierarchy, tissue culture, in-vivo modelling, RNA-sequencing, and metabolic assays. The project is based in the Mistry and Rushworth Lab at Norwich Medical School, University of East Anglia, and is embedded in a collaborative environment spanning stem cell biology and metabolism, with links to the Earlham Institute and the wider Norwich Research Park.

This studentship is well suited to applicants with a background in molecular biology, cell biology, immunology, genetics, or a related bioscience subject, especially those interested in stem cell biology or ageing. The position is funded as a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD studentship, including tuition fees, an annual stipend, and research training support.

Deadline: 30 November 2026 at 23:59. Applications are made via the UEA Apply link on the advertisement page.

Funding details

Available

What's required

Applicants should have a background in molecular or cell biology, immunology, genetics or a related bioscience discipline, and an interest in stem cell biology or ageing. The project would suit someone able to work across flow cytometry, tissue culture, in-vivo modelling, RNA-sequencing and metabolic assays; no specific language tests or grades are mentioned in the posting.

How to apply

Click the Apply button on the UEA advert page to submit your application. Ensure it is completed by 23:59 on 30 November 2026.

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