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University of East Anglia

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PhD Studentship: Cloaks and Daggers: Fitness Effects of Ceratotoxin Antimicrobials in a Global Fruit Fly Pest University of East Anglia in United Kingdom

Degree Level

PhD

Field of study

Molecular Biology

Funding

Available

Deadline

Dec 16, 2026

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Country

United Kingdom

University

University of East Anglia

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Keywords

Molecular Biology
Environmental Science
Agriculture
Biology
Entomology
Microbiome Research
Antimicrobial Peptide
Bioinformatic

Suggested scholarships

About this position

[Fully funded studentship covering fees, a maintenance stipend of £21,805 p.a. for 2026/27, and a research training and support grant (RTSG). Limited international studentships available with the home/international fee difference waived; relocation, visa, and UK health surcharge costs are not covered.]

PhD Studentship at the University of East Anglia in the ARIES Ecology and Biodiversity theme.

This project, titled Cloaks and Daggers: Fitness Effects of Ceratotoxin Antimicrobials in a Global Fruit fly Pest, explores how medfly mothers (Ceratitis capitata) coat their eggs with broad-spectrum antimicrobial peptides known as Ceratotoxins. The research asks why this egg “cloak” exists, how redundant Ceratotoxin genes function, and whether these molecules could ultimately support insect control strategies for pests that threaten food security.

The studentship offers strong interdisciplinary training in phenotypic engineering, molecular genetics, microbiology, bioinformatics, and sequencing. The research plan includes fitness assays under natural or semi-natural conditions, microbial manipulations, 16S rDNA profiling of microbial communities, CRISPR-Cas9 knock-outs, synthetic peptide testing, and downstream analysis of the evolutionary and applied significance of antimicrobial egg cloaking.

Key scientific questions include whether Ceratotoxins protect eggs and larvae from harmful microbes, protect the female reproductive tract from sexually transmitted infections, help establish beneficial microbial communities, or enable vertical transmission of helpful microbes. A second focus is whether Ceratotoxin redundancy is adaptive, using gene-edited medflies and synthetic peptide mixtures to test antimicrobial spectrum and potency. A third direction explores applied pest-control possibilities such as female-specific lethality, fertility reduction, X-chromosome shredding, and probiotics.

The award is fully funded for eligible candidates and covers fees, a maintenance stipend of £21,805 per year for 2026/27, and a research training and support grant (RTSG). A limited number of studentships are available for international applicants, with the home/international fee difference waived by the university. ARIES notes that relocation, visa, and UK health surcharge costs are not covered.

The project sits in a supportive and inclusive research environment. The advertisement states that academic qualifications are considered alongside non-academic experience, with equal weighting for experience and potential. The deadline is 16 December 2026. Applications are made through the University of East Anglia postgraduate research application portal, and applicants must also complete the ARIES Equality and Diversity Form for 2027 entry.

Funding details

Available

What's required

Applicants should be interested in interdisciplinary research in ecology, biodiversity, phenotypic engineering, molecular genetics, microbiology, sequencing, and gene editing. Academic qualifications are considered alongside non-academic experience, with equal weighting given to experience and potential. UKRI eligibility criteria apply for full funding; international applicants may be eligible for a limited number of studentships subject to fee waiver arrangements.

How to apply

Apply through the University of East Anglia postgraduate research application portal. Submit an application for the relevant ARIES project and complete the ARIES Equality and Diversity Form for 2027 entry. If applying for more than one project, submit a separate form for each.

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