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University of Southampton

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AI-Guided Discovery of Immunotherapy Resistance Mechanisms PhD at University of Southampton University of Southampton in United Kingdom

Degree Level

PhD

Field of study

Computer Science

Funding

Funded PhD studentship supported by philanthropic donation. Covers University international fees, a stipend of approximately £22,500 per year with inflationary increases, and experimental consumables for 3 years.

Deadline

Jan 10, 2027

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Country

United Kingdom

University

University of Southampton

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Keywords

Computer Science
Biomedical Engineering
Biology
Tumor Microenvironment
Tumor Immunology
Statistics
Bioinformatic
ML

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About this position

PhD opportunity at the University of Southampton in AI-Guided Discovery of Immunotherapy Resistance Mechanisms.

This funded project sits in the Faculty of Medicine and combines cancer biology, immunology, bioinformatics, machine learning, and single-cell RNA sequencing. The research aims to understand why anti-cancer immune cells lose effectiveness inside tumours, with a focus on T-cell exhaustion, the tumour micro-environment, and resistance to therapies such as CAR-T.

The student will analyse and integrate single-cell datasets, apply and adapt machine-learning and gene-regulatory network approaches, and then experimentally validate the most promising predictions using cell culture, multi-colour flow cytometry, functional immunological assays, and molecular biology techniques. This is a strong fit for applicants interested in the interface of computational biology and wet-lab biomedical research.

Supervisory team: Prof Sean H Lim and Prof Owen Rackham.

Funding: fully funded studentship supported by philanthropic donation, covering international tuition fees, a stipend of about £22,500 per year (with inflationary increase), and experimental consumables for 3 years.

Eligibility: undergraduate degree at 1st or 2:1 level (or international equivalent) in bioinformatics, computational biology, biological sciences, immunology, or a related field. The advert states that the studentship is reserved for international students, with Malaysians and Singaporeans particularly encouraged.

Start date: September 2027. Duration: 3 years.

How to apply: submit an online application through the University of Southampton postgraduate research portal and include a CV, two reference letters, and degree transcripts to date. Initial enquiries can be sent to Prof Sean Lim at [email protected].

Funding details

Funded PhD studentship supported by philanthropic donation. Covers University international fees, a stipend of approximately £22,500 per year with inflationary increases, and experimental consumables for 3 years.

What's required

An undergraduate degree at 1st or 2:1 level (or international equivalent) in bioinformatics, computational biology, biological sciences, immunology, or a related discipline. The successful candidate should be highly motivated and intellectually curious, and comfortable combining computational and experimental research across disciplinary boundaries.

How to apply

Apply online via the University of Southampton postgraduate research application page. Submit a CV, two reference letters, and degree transcripts to date. For an initial conversation, contact Prof Sean Lim by email.

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