Steve Jackson
Top university
1 year ago
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Cancer research and radiation therapy University of Cambridge in United Kingdom
Degree Level
PhD
Field of study
Biomarker Research
Funding
Funding includes a four-year stipend, tuition fees at the Home rate, and an allocation towards project consumables and training. International students must secure additional funding to cover the difference in fees.
Deadline
Oct 1, 2026
Country
United Kingdom
University
University of Cambridge
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About this position
Funding details
Funding includes a four-year stipend, tuition fees at the Home rate, and an allocation towards project consumables and training. International students must secure additional funding to cover the difference in fees.
What's required
Applicants should have relevant research experience, ideally in cancer biology, radiotherapy, or related biomedical sciences. The position is open to UK citizens, overseas students meeting UK residency requirements, or those able to cover the difference in international fees through additional funding. Strong research background and interest in cellular mechanisms and genetic screens are preferred.
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Professors
Professor Sir at University of Cambridge
United Kingdom
Research Interests
Crispr/cas9
Radiation Therapy
Health Science
Dna Damage
Cancer Biology
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University of Cambridge - Cancer Research UK Cambridge Institute (CRUK CI) and the AstraZeneca Discovery Centre
Supervisors: Professor Sir Steve Jackson and Dr Mark O'Connor (AZ Partner)
Course start date: 1st October 2026
Funding: Funding includes a stipend for four years, tuition fees (at Home rate only) and an allocation towards project consumables and training.
Eligibility: Applicants with relevant research experience are strongly encouraged to apply.
The position is open to UK citizens, or overseas students meeting the UK residency requirements, or able to cover the difference in international fees through additional funding awards.
Project details
Targeted Alpha Therapy (TAT) selectively delivers high Linear Energy Transfer (LET) alpha-particles to cancer cells, maximising efficacy while minimising toxicity. Knowledge about radiation sensitivity, accrued mainly with sparsely ionising low-LET radiation (e.g. X-ray, -ray), demonstrated that genetic backgrounds influence radiation therapy (RT) responses, with DNA-damage response (DDR) pathways critically involved. However, determinants of sensitivity to high-LET radiation, such as alpha particles emitted by TAT, remain largely unexplored.
Emerging data suggest that some cancer cells within the alpha particle emission path only receive sub-lethal levels of DNA damage and can survive. Combining TAT and DDR inhibitors thus has the potential to convert this sub-lethal DNA damage into cancer cell killing.
This project will explore the effects of radioligand therapies on cell viability and DDR activation in established human cell models. The student will perform CRISPR screens to determine factors that affect resistance/sensitivity and follow these up with mechanistic studies of a shortlist of identified targets. These studies may uncover mechanisms of cellular responses, potential biomarkers and additional therapeutic vulnerabilities that underlie the responses of normal and tumour cells to alpha radiotherapy.
Apply here: https://lnkd.in/eGCVMtC3
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