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Centers for Disease Control and Prevention
3 days ago
CDC Development of Long-Read DNA Sequencing for Newborn Screening Disorders Centers for Disease Control and Prevention (CDC) in United States
Degree Level
Postdoc
Field of study
Biology
Funding
Participant stipend is provided; exact monthly stipend rate varies by opportunity, location, education, and experience. Appointment is initially for one year and may be renewed depending on CDC recommendation and availability of funds.
Deadline
Dec 4, 2026
Country
United States
University
Centers for Disease Control and Prevention
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About this position
This fellowship at the Centers for Disease Control and Prevention (CDC) places the participant in the Newborn Screening and Molecular Biology Branch within the Division of Laboratory Sciences at the National Center for Environmental Health in Atlanta, Georgia. The work is embedded in an ISO-accredited laboratory environment supporting newborn screening laboratories through molecular assay development, technology transfer, training, quality assurance materials, and assistance to public health programs expanding screening tests.
The project centers on applying long-read DNA sequencing to complement current short-read whole genome sequencing approaches used in newborn screening quality assurance and assay development. The participant will work on characterizing gene deletions and resolving complex haplotypes in genomic regions where highly similar pseudogenes make variant interpretation difficult. The research aims to build and validate long-read workflows that can distinguish functional genes from pseudogenes and better resolve structural variants that are challenging to detect with short-read data alone.
Example disorder areas include Duchenne muscular dystrophy, spinal muscular atrophy, and hemoglobinopathies, with specific attention to difficult loci such as DMD, SMN1/SMN2, alpha-globin gene clusters, and HBB-related pseudogene regions. The work is designed to improve the accuracy and reliability of molecular reference materials and testing methods used by state and local public health laboratories.
The training environment emphasizes both wet-lab and computational development. The participant will gain experience with long-range PCR, long-read library preparation for Oxford Nanopore and PacBio platforms, and bioinformatic analysis of long-read sequencing data, including structural-variant calling, haplotype phasing, and pseudogene resolution. The fellowship also includes comparing long-read and short-read whole-genome sequencing outputs, developing molecular assays for complex genomic regions, managing genomic data with specialized pipelines, and communicating results through presentations and manuscripts.
The named mentor for this opportunity is Christopher Greene.
Funding details
Participant stipend is provided; exact monthly stipend rate varies by opportunity, location, education, and experience. Appointment is initially for one year and may be renewed depending on CDC recommendation and availability of funds.
What's required
The qualified candidate should have received a doctoral degree in genetics, molecular biology, genomics, bioinformatics, or a related field within the past five years. U.S. citizenship or lawful permanent resident status is required. Preferred qualifications include experience with next-generation sequencing and long-read platforms such as Oxford Nanopore or PacBio, bioinformatic analysis including variant calling, structural variant analysis, and/or haplotype phasing, familiarity with pseudogene-rich or highly homologous genomic regions, proficiency in molecular techniques such as DNA extraction, PCR, real-time PCR, and sequencing, plus strong organizational, independent-working, teamwork, and written/oral communication skills.
How to apply
Scroll to the bottom of the opportunity page and click APPLY. Submit the application, transcripts, current CV/resume, one recommendation, and a copy of an abstract or article reprint. Ensure all documents are in English or accompanied by an official English translation.
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