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Institut Curie

Chromosome Biology Post-doc position (F/M) Institut Curie in France

Degree Level

Postdoc

Field of study

Biophysics

Funding

Available

Deadline

Dec 7, 2026

Country flag

Country

France

University

Institut Curie

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Keywords

Biophysics
Biology
Medical Science
Transcriptional Regulation
Dna Repair
Super-resolution Microscopy
Chromosome
Physics

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About this position

The successful candidate will join the Leonid Mirny team at Institut Curie, working within the ERC GeneMotors program and affiliated with Institut Curie UMR 3664 in Paris and the Massachusetts Institute of Technology. The group studies the physical principles of genome organization and how they shape cellular function, bringing together theoretical modeling, computational approaches, and close collaboration with experimental partners.

This postdoctoral project focuses on cohesin-mediated loop extrusion, chromatin folding, and long-range gene regulation. The researcher will help develop and validate quantitative models of genome regulation, with a particular emphasis on centromere organization and DNA repair. The work combines chromosome biology with model-driven experiments and aims to clarify how SMC-mediated loop extrusion dynamics influence chromosome function.

The role includes designing sister-resolved Hi-C protocols, generating Hi-C data for centromeres, collecting super-resolution microscopy data on centromere organization and chromosome translocations, and quantitatively analyzing genomic, Hi-C, and imaging datasets. The postdoc will work in an international collaborative setting and contribute to scientific publications and presentations as the models are refined through close interaction with computational and experimental collaborators.

Institut Curie provides a research environment centered on cancer research and close interaction between scientists, clinicians, and healthcare professionals.

Funding details

Available

What's required

PhD or equivalent in Biology, Physics or Biophysics. Excellent fluency in English is required; French is listed as excellent in the requirements section. The candidate should have a solid background in chromosome biology, extensive experience in Hi-C and other genomic techniques, experience in quantitative analysis of biological datasets (genomics, transcription, or imaging data), the ability to work independently while engaging in interdisciplinary collaboration, and the ability to bridge modeling and experimental data in an iterative, hypothesis-driven framework. Research experience of 1–4 years is indicated.

How to apply

Send your CV and letter of motivation by email to [email protected]. Use the application email provided in the advert. Applications are accepted until the position is filled.

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