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Institut Curie

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Postdoctoral Researcher in Chromosome Biology, Cohesin Loop Extrusion and Genome Organization Institut Curie in France

Degree Level

Postdoc

Field of study

Biophysics

Funding

This is a full-time 12-month fixed-term postdoctoral contract in Paris. Gross annual salary is €36,219–€39,808 according to applicable salary scales. Benefits include a staff restaurant, 75% reimbursement of the annual public-transport pass, and company health insurance.

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Country

France

University

Institut Curie

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Keywords

Biophysics
Biology
Transcriptional Regulation
Dna Repair
Super-resolution Microscopy
Chromosome
Bioanalysis

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About this position

The Institut Curie is recruiting a postdoctoral researcher to join the team led by Leonid Mirny at the Institut Curie Research Center in Paris, affiliated with Institut Curie and the Massachusetts Institute of Technology through the ERC-funded GeneMotors project.

The team investigates the physical principles governing genome organization and their effects on cellular function. Its research combines theoretical modeling, computational approaches and close interaction with experimental collaborators, with particular emphasis on cohesin-mediated loop extrusion, chromatin folding and long-range communication between enhancers and promoters.

The postdoctoral researcher will contribute to the development and experimental validation of quantitative models of genome regulation. The project will examine how cohesin-driven loop extrusion controls long-range gene regulation and other chromosome functions, including centromere organization and DNA repair mediated by SMC proteins.

Research activities will include developing Hi-C protocols capable of distinguishing sister chromatids, generating Hi-C data for centromeres, acquiring super-resolution microscopy data on centromere organization and chromosomal translocations, and quantitatively analyzing genomic, Hi-C and imaging datasets. The researcher will work closely with computational and experimental scientists to iteratively refine physical predictions and will contribute to publications and presentations within an international consortium.

The position offers an interdisciplinary research environment at a leading cancer research center, connecting chromosome biology, biophysics, genome-wide technologies, quantitative imaging and computational modeling.

Funding details

This is a full-time 12-month fixed-term postdoctoral contract in Paris. Gross annual salary is €36,219–€39,808 according to applicable salary scales. Benefits include a staff restaurant, 75% reimbursement of the annual public-transport pass, and company health insurance.

What's required

Applicants must hold a PhD in physics, biophysics or biology, have excellent English proficiency, solid knowledge of chromosome biology, and very good experience with Hi-C and other genomic techniques. Experience in quantitative analysis of biological data, including genomic, transcriptional or imaging data, is required. Candidates should be able to work independently, contribute actively to interdisciplinary collaborations, and connect modeling with experimental data in an iterative, hypothesis-driven framework.

How to apply

Submit a CV and cover letter through the Institut Curie/Université PSL recruitment page. Applications are accepted until the position is filled.

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