Computational Postdoctoral Research Associate in Molecular Simulations for Gram-Negative Antibiotic Discovery University of Oxford in United Kingdom

University of Oxford-based postdoctoral researcher opportunity in the Gram-Negative Antibiotic Discovery Innovator (Gr-ADI) project. The project is focused on antibiotic discovery and uses molecular simulation to assess, for each lead compound/target protein pair, how many mutations could lead to resistance. This is an interdisciplinary role at the interface of chemistry, biology, medical science, pharmacy, and computational research. Ideal applicants will have a PhD and experience in molecular ...

Industry-based PhD studentship at GSK R&D in collaboration with the University of Strathclyde, Department of Chemistry . The programme, titled “Building a Career in Drug Discovery at GSK” , offers PhD research in medicinal chemistry , chemical biology , or structural biophysics and in silico modelling . The project is co-supervised by Strathclyde chemistry academics and a senior GSK scientist, with research aligned to modern drug discovery. Research themes include design and development of moder...

PhD opportunity at the University of York in machine learning-guided sustainable automated synthesis and target-based screening of metal-based antibiotics . This project sits at the interface of computational chemistry , inorganic chemistry , and pharmaceutical chemistry , with a strong focus on antimicrobial resistance , antibiotic discovery , and data-driven molecular design. The student will use miniaturised, automated high-throughput synthesis to prepare libraries of transition metal complex...

PhD opportunity in Engineering Biology at the University of Bristol , offered in collaboration with Prof Dek Woolfson through the SWBio DTP . The project is titled Engineering co-translational protein assembly using de novo designed proteins (Project ID: 3544). It asks how proteins assemble while being synthesised on the ribosome, building on advances in protein structure prediction such as AlphaFold and focusing on the folding and assembly of de novo designed coiled-coil proteins during transla...

AstraZeneca-funded PhD studentship at the University of Cambridge in the Department of Pure Mathematics and Mathematical Statistics . The project, Physics-Guided Representation Learning from Free Energy Perturbation Data for Affinity Prediction and Candidate Down-Selection , sits at the interface of statistical machine learning , molecular simulation , drug discovery , and computational chemistry . The successful student will work on developing new machine-learning methods for predicting molecul...