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US Food and Drug Administration

FDA Fellowship: RLD vs. Generic Buprenorphine Films — A Physicochemical Study of Equivalence & Manipulability U.S. Food and Drug Administration (FDA) in United States

Degree Level

Postdoc

Field of study

Chemistry

Funding

Monthly stipend commensurate with educational level and experience; appointment initially for one year and may be renewed subject to FDA recommendation and availability of funds.

Deadline

Dec 15, 2026

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Country

United States

University

US Food and Drug Administration

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Keywords

Chemistry
Materials Science
Multivariate Analysis
Regulatory Science
Raman Spectroscopy
Atomic Force Microscopy
Chemometric

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About this position

This FDA research fellowship at the Center for Drug Evaluation and Research (CDER) in St. Louis, Missouri examines the micro- and nanoscale structure of buprenorphine sublingual films and how structural differences between reference listed drug and generic formulations may influence product performance.

The project is centered on Q3 microstructural sameness, with the fellow comparing reference and generic films to better understand links between structure, composition, and critical quality attributes such as dissolution, dose uniformity, and abuse potential. The work sits within FDA’s regulatory science mission and contributes to the scientific evaluation of complex drug products.

The research environment emphasizes advanced physicochemical characterization and multimodal analysis. The fellow will work with complementary techniques including SEM, cryo-SEM, Raman chemical imaging, and AFM-IR/nanoIR to study surface and cross-sectional features, local chemical composition, polymer–drug interactions, and spatial heterogeneity in complex pharmaceutical matrices.

The project also develops skills in chemometrics, multivariate analysis, and reproducible data-processing workflows, integrating structural, chemical, and nanoscale datasets to build a deeper understanding of pharmaceutical film materials than a single method can provide. The opportunity offers hands-on experience in a multidisciplinary FDA setting focused on modern analytical characterization of drug products.

The mentor for this opportunity is Snober Ahmed at FDA CDER.

Funding details

Monthly stipend commensurate with educational level and experience; appointment initially for one year and may be renewed subject to FDA recommendation and availability of funds.

What's required

The candidate must have received a doctoral degree in a relevant field within the past five years. The opportunity is open only to U.S. citizens and Lawful Permanent Residents, and applicants must have lived in the United States for at least 36 of the past 60 months. Preferred preparation includes materials characterization, pharmaceutical sciences, analytical chemistry, materials science, polymer science, advanced chemical imaging, quantitative data analysis, AFM-IR/nanoIR, AFM-based techniques, SEM, Raman spectroscopy/chemical imaging, cryo-SEM, chemometrics, dissolution and drug-release principles, and experience with polymers, pharmaceutical formulations, thin films, amorphous materials, or other complex multicomponent materials. Strong oral and written scientific communication, analytical thinking, attention to data quality and reproducibility, and ability to work independently and collaboratively are preferred.

How to apply

Submit the application through the APPLY button on the Zintellect opportunity page. Include the application form, transcripts, current resume/CV, and one educational or professional recommendation, with all documents in English or accompanied by official English translations. For questions, email [email protected] and include the reference code FDA-CDER-2026-0173.

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