Fully Funded PhD in AI Protein Design, Structural Biology, and Plant Immune Receptors at Durham University Durham University in United Kingdom

Fully funded PhD project in AI protein design, structural biology, plant immunity, bioinformatics, biophysics, biochemistry, molecular biology, and plant biology at the University of Cambridge / Bentham Lab network, with co-supervision from Marc Knight . The project aims to design synthetic plant immune receptors from first principles, using generative AI tools such as RFdiffusion, ProteinMPNN and BindCraft, together with structural bioinformatics, X-ray crystallography, cryo-EM, and in planta f...

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

PhD opportunity at King’s College London in the Randall Centre for Cell & Molecular Biophysics on molecular mechanisms of RNA–protein interactions and their dysregulation in human disease . This project focuses on how RNA-binding proteins (RBPs) recognize structured RNA elements, how their conformations are remodeled, and how post-translational modifications such as phosphorylation regulate translation and complex assembly. The research combines structural biology , biophysics , RNA biochemistry...

PhD opportunity in pathological protein assembly in neurodegenerative diseases at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom . The project is centered on the molecular pathology of neurodegeneration, with a focus on amyloid filament formation by disease-associated proteins such as TDP-43 , annexin A11 , and TAF15 . Two PhD project directions are described. One aims to reproduce pathological protein filament structures in vitro using protein biochemist...

PhD project at the University of Bath within the GW4 BioMed3 MRC Doctoral Landscape Programme (DLP) : Decoding Neurodevelopmental Disorders: From Patient Variants to Disease Mechanisms . This is a competition-funded PhD project for entry in September 2027 , with up to 17 studentships available across the GW4 BioMed3 partnership (Bath, Bristol, Cardiff, Exeter). The project investigates how disease-associated variants in HECTD1 affect protein stability, ubiquitin ligase activity, signalling pathw...