Funded PhD in Chromosome Organisation by Dynamic Cohesin Complexes The Francis Crick Institute in United Kingdom

PhD Studentship in the Biochemistry and Chemical Biology of the Genome and Epigenome at the University of Cambridge , Department of Chemistry. This funded PhD project is offered in Professor Sir Shankar Balasubramanian’s group and focuses on biochemistry , chemical biology , genomics , molecular biology , biophysics , and structural biology . The research explores fundamental mechanisms of genome function, with a strong emphasis on DNA secondary structures such as G-quadruplexes (G4s) , chromati...

PhD opportunity in pathological protein assembly in neurodegenerative diseases at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom . The project is centered on the molecular pathology of neurodegeneration, with a focus on amyloid filament formation by disease-associated proteins such as TDP-43 , annexin A11 , and TAF15 . Two PhD project directions are described. One aims to reproduce pathological protein filament structures in vitro using protein biochemist...

PhD opportunity at The Francis Crick Institute with Dr Peter Rosenthal on cryomicroscopy of lipid-enveloped virus entry and assembly . The project sits at the intersection of structural biology , virology , cell biology , and biophysics , with a strong emphasis on cryo-EM , cryo-ET , and related imaging/computational methods. The research aims to directly image key steps in infection by lipid-enveloped viruses such as influenza and retroviruses . Topics include virus entry, receptor binding, mem...

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

PhD opportunity at The Francis Crick Institute in London, United Kingdom: Enabling antibiotics discovery by targeted protein degradation with Dr Francesca Ester Morreale. This funded PhD project focuses on targeted protein degradation (TPD) in pathogenic bacteria as a new strategy for antibiotic discovery . The project will explore how to design novel antibiotic degraders and study their mechanism of action using biochemistry , biophysics , proteomics , and molecular microbiology . The lab’s bro...