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Arturo López Castel

1 year ago

Molecular Life Sciences, Physiology, Biomedical Sciences University of Valencia in Spain

Degree Level

PhD

Field of study

Neuroscience

Funding

MSCA multidisciplinary doctoral network

Deadline

Expired

Country flag

Country

Spain

University

University of Valencia

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Keywords

Neuroscience
Cell Biology
Physiology
Molecular Biology
Chemistry
Biomedical Engineering
Biology
Rna Biology
Neuropsychology
Immunohistochemistry
Strength And Conditioning
Pharmaceutical Chemistry
Mirna
Omics
Cell Culture Techniques
Genomic
Phenotypic Screening
Muscular Atrophy
Biomedicine

About this position

HIRING TWO DOCTORAL CANDIDATES

We participate in ENTRY-DM, an MSCA multidisciplinary doctoral network aimed at developing oligonucleotide-based therapies and preparing clinical trials in myotonic dystrophy, through advanced doctoral training. It brings together 11 European laboratories and 18 international partners with expertise in disciplines as varied as medicinal chemistry, genetics, multi-omics, bioengineering and neuropsychology. The network is recruiting 14 doctoral candidates through Euraxess under the leadership of Mario Gomes-Pereira. Within the network, our laboratory seeks two Doctoral Candidates (DC) who will enjoy a dynamic environment at the University of Valencia and close contact with ARTHEX Biotech, a spin-off company from our laboratory.

DC6 will focus on understanding the mechanisms by which MBNL translational repressor miRNAs are misregulated in DM1, their contribution to the disease, and how DMPK levels change in response to antimiRs. You will use muscle models such as immortalized patient-derived cells and human primary myoblasts.

link to DC6 position:
https://lnkd.in/ewybXtbq

DC9 will aim to discover means to enhance therapeutic antisense oligonucleotides by improving cellular uptake and endosomal escape, including genetic and drug screens using reporter cell lines. Effective approaches will be prioritized, and mechanisms of action will be defined. Results will be validated in DM1 disease models, evaluating hallmark features like RNA foci, and muscle strength using patient-derived cells and transgenic mice:

link to the DC9 position:
https://lnkd.in/e3ua4H62

Candidate Profile: We seek a highly motivated and ambitious candidate with a strong genetics and cellular biology background, particularly in RNA-based therapeutics. The ideal candidate should hold a Master’s degree in Molecular Life Sciences, Physiology, Biomedical Sciences, or a related field, with hands-on experience in gene and protein quantification techniques, immunofluorescence, and cell culturing.

Application Process (before deadline May 30th): Submit a single PDF document to Ruben Artero (DC6; [email protected] ), or Arturo López Castel (DC9; [email protected] ), and [email protected] , including your CV, motivation letter, academic certificates, proof of English proficiency, national identity card, and two recommendation letters.

Funding details

MSCA multidisciplinary doctoral network

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University Name
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Spain

Research Interests

Pharmacology

Pharmaceutical Chemistry

Ataxia

Pharmaceutic

Photopharmacology