MSc in High-Throughput Screening for Endosomal Escape Enhancers in Cancer Vaccines at Université de Montréal Université de Montréal in Canada

The Rafei Lab at the Université de Montréal is seeking an outstanding MSc candidate for a research project focused on high-throughput screening to identify novel endosomal escape enhancers, supporting the development of cell-based cancer vaccines. The position is based in the Department of Pharmacology & Physiology and will leverage the resources of IRIC’s High-Throughput Screening Core Facility, providing access to a large chemical compound library (~120,900 compounds) and advanced screening technologies.

The research will involve developing and miniaturizing a quantitative endosomal escape assay suitable for automation, running a primary screen, performing confirmation and specificity triage, and validating prioritized hits in biologically relevant assays. The project sits at the intersection of immunology, cancer biology, and screening science, with a strong emphasis on experimental rigor and reproducibility.

Applicants should demonstrate academic excellence, motivation for biomedical research, and the ability to work in a high-throughput environment. Preferred qualifications include prior lab experience in mammalian cell culture and exposure to flow cytometry and quantitative data analysis. The application requires a single PDF with a CV, unofficial transcripts, a one-page cover letter, and contact details for two references. Applications should be sent to [email protected] with the subject 'MSc HTS - Endosomal Escape'.

The Université de Montréal is a leading research institution in Canada, and this opportunity provides hands-on experience in advanced screening and cancer vaccine development. The selection process is competitive, with shortlisting based on academic excellence, experimental maturity, and fit with the project’s needs.