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Bastiaan Krom

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PhD Candidate EPIC Project: Endolysin-Based Therapies Against Implant-Associated Biofilm Infections Vrije Universiteit Amsterdam in Netherlands

Degree Level

PhD

Field of study

Biomedical Engineering

Funding

PhD position with a salary of €3,204 to €4,051 gross per month on a full-time basis; 4-year PhD contract (initial 1 year, extended by 3 years after positive evaluation).

Deadline

Nov 16, 2026

Country flag

Country

Netherlands

University

Vrije Universiteit Amsterdam

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Keywords

Biomedical Engineering
Materials Science
Biology
Biosecurity
Antibiotic Resistance
Medical Science
Immune Response
Host-pathogen Interaction
Staphylococcus Aureus
Biomaterials

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About this position

This PhD project focuses on developing and evaluating endolysin-based therapies against implant-associated biofilm infections. The work is part of the NWO-funded EPIC consortium, which brings together ACTA, the University of Twente, Micreos, LipoCoat, and clinical partners to develop endolysin-loaded nanocarriers for preventing and treating infections linked to prosthetic implants.

You will investigate how novel endolysin formulations perform against clinically relevant staphylococcal pathogens, including Staphylococcus aureus, Staphylococcus epidermidis, and MRSA, in both planktonic and biofilm settings. The project also includes the development of advanced in vitro infection systems, such as microfluidic models, to study intracellular staphylococci, resistance development, cytotoxicity, immune responses, and effects on bone-related cells.

The position is embedded in an interdisciplinary research environment at ACTA, where you will be based in both the Department of Preventive Dentistry and the Department of Oral Cell Biology. The project connects microbiology, cell biology, biomaterials, and host-microbe interactions, and includes collaboration with academic and industrial consortium partners. You will also contribute to scientific publications and conference presentations during the PhD.

The supervisory team consists of Prof. dr. Bastiaan Krom, Prof. dr. Astrid Bakker, dr. ing. Michel Hoogenkamp, and dr. Jianfeng Jin at ACTA, part of Vrije Universiteit Amsterdam.

Funding details

PhD position with a salary of €3,204 to €4,051 gross per month on a full-time basis; 4-year PhD contract (initial 1 year, extended by 3 years after positive evaluation).

What's required

A Master's degree or near completion in Microbiology, Biomedical Sciences, Molecular Biology, Cell Biology, Immunology, Biotechnology, Biochemistry, or a related field is required. Applicants should have experience with microbiology, biofilm research, mammalian cell culture, molecular biology, and/or microscopy. Strong analytical and communication skills, an interest in translational biomedical research and antimicrobial resistance, the ability to work independently and in a multidisciplinary team, and excellent English language skills are required. Applicants already eligible to work in the Netherlands are strongly encouraged to apply; applications requiring immigration sponsorship may not be prioritized.

How to apply

Submit a motivation letter, CV, and contact details of two academic references through the application portal. A diploma must be submitted as part of the application process. Applications by email will not be considered.

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Professors

Prof. dr. at Vrije Universiteit Amsterdam

University Name
Country flag

Netherlands

Research Interests

Biomaterials

Medical Science

Antibiotic Resistance

Biology

Immune Response

Prof. dr. at Vrije Universiteit Amsterdam

University Name
Country flag

Netherlands

Research Interests

Biomaterials

Immune Response

Host-pathogen Interaction

Staphylococcus Aureus

Biomedical Engineering