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Kumar Somyajit

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PhD fellowship in DNA replication and genome stability after whole-genome doubling University of Southern Denmark in Denmark

Degree Level

PhD

Field of study

Biology

Funding

Fully funded PhD fellowship with a monthly salary including pension, office facilities, and financial support for conference travels and research visits abroad.

Deadline

Dec 11, 2026

Country flag

Country

Denmark

University

University of Southern Denmark

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Keywords

Biology
Stem Cell Biology
Mass Spectrometry
Medical Science
Genome Stability
Dna Replication
Cell Cycle Regulation

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About this position

The Somyajit laboratory at the University of Southern Denmark invites applications for a fully funded PhD fellowship in the Quantitative Cell Biology and Bioimaging research unit at the Department of Biochemistry and Molecular Biology. The project sits at the intersection of cell cycle control, DNA replication, and genome surveillance, and is designed around a fundamental question in how cells cope when their genome doubles.

The PhD student will investigate how whole-genome doubling reshapes the capacity of the replication and chromatin-maintenance machinery in non-transformed cells, cancer cells, and mouse embryonic stem cells. A central focus is the dosage-sensitive regulator PAF15 and its role in supporting PCNA on chromatin during DNA replication and repair. Building on recent findings from the group, the project will explore whether whole-genome doubling creates bottlenecks in genome copying and maintenance, how cells adapt to those limits, and whether these adaptations expose vulnerabilities that could be exploited in cancer.

The work combines quantitative cell biology, genome engineering, and biochemical approaches. The student will use quantitative image-based cytometry, live-cell imaging, super-resolution microscopy, DNA fibre assays, CRISPR-based perturbation, stem-cell culture and differentiation, and chromatin-resolved mass spectrometry.

The project is embedded in an international and interdisciplinary environment with advanced facilities for bioimaging, sequencing, flow cytometry, mass spectrometry, metabolomics, and transgenic mouse work. The group collaborates within the Department of Biochemistry and Molecular Biology and has strategic research links with Odense University Hospital.

Funding details

Fully funded PhD fellowship with a monthly salary including pension, office facilities, and financial support for conference travels and research visits abroad.

What's required

Applicants should have a master’s degree in Life Science, preferably Molecular Biology, Cell Biology, or Biomedicine (5+3 programme). A strong interest in cell cycle, DNA replication, and genome integrity is required, along with relevant laboratory experience in quantitative imaging and genome editing. Experience in genome integrity research, stem cell culture, light microscopy, and bioinformatics is considered an advantage. Candidates must have strong communication and collaborative skills, be comfortable working in an interdisciplinary environment, and have proficiency in spoken and written English.

How to apply

Apply online through the provided link and submit a Declaration of Interest in English. Include a motivation letter, CV, diplomas and transcripts, and contact details for at least two referees. Upload the documents as three PDF files and consult the SDU how-to-apply information before submitting.

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Professors

Associate Professor at University of Southern Denmark

University Name
Country flag

Denmark

Research Interests

Cell Biology

Biochemistry

Genome Stability

Dna Replication

Metabolic Biology