Publisher
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MRC Laboratory of Molecular Biology

PhD in Biochemistry, Cancer Biology, and Molecular Biology on mTORC2 activation loops Medical Research Council Laboratory of Molecular Biology in United Kingdom

Degree Level

PhD

Field of study

Biochemistry

Funding

Competition funded PhD project. Funding details are not specified in the post, but the project is described as funded and open to students worldwide.

Deadline

Dec 8, 2026

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Country

United Kingdom

University

MRC Laboratory of Molecular Biology

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Keywords

Biochemistry
Molecular Biology
Cancer Biology
Biology
Molecular Dynamics
Cryo-electron Microscopy
Medical Science

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About this position

PhD opportunity at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom on mTORC2 activation, AKT signaling, and related biochemistry, cancer biology, and molecular biology questions.

The project focuses on how mTORC2 integrates activating inputs to control anabolism, survival, and cytoskeletal remodelling, with emphasis on positive feedback loops and upstream activation mechanisms. The student will help elucidate natural mechanisms of mTORC2 activation and may also explore small-molecule mTORC2 activators developed in collaboration with AstraZeneca.

Research methods mentioned include single-particle cryo-EM, tomographic cryo-EM, membrane-associated structural studies, in vitro reconstitution of mTORC1/mTORC2 signaling, molecular dynamics, AI-generated ensembles, and HDX-MS. The work is highly interdisciplinary and sits at the interface of structural biology, signaling, and translational cancer research.

This is a competition funded PhD project and is open to students worldwide. The post does not specify stipend amount, tuition coverage, or additional financial terms.

Applications are handled through the FindAPhD enquiry/register-interest flow, and the university will respond directly to applicants. The page lists a deadline of 2026-12-08.

Funding details

Competition funded PhD project. Funding details are not specified in the post, but the project is described as funded and open to students worldwide.

What's required

Applicants should be interested in biochemistry, cancer biology, and molecular biology. The project involves structural biology and computational/biophysical methods including single-particle and tomographic cryo-EM, in vitro reconstitution of signaling pathways, molecular dynamics, AI-generated ensembles, and HDX-MS. The post is a competition-funded PhD project open to students worldwide.

How to apply

Register your interest through the FindAPhD page. The university will respond directly to enquiries submitted via the site.

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