PhD in Structures and Mechanisms of the Human Replisome Medical Research Council (Cambridge) Laboratory of Molecular Biology in United Kingdom

PhD opportunity in DNA repair at stalled replication forks at the Medical Research Council (Cambridge), Laboratory of Molecular Biology in the United Kingdom . The project focuses on DNA repair , replication stress , and the Fanconi Anaemia (FA) pathway , with particular attention to how cells respond to DNA crosslinks and stalled replication forks. The research aims to understand the molecular mechanisms of crosslink repair and the role of the FANCD2-FANCI heterodimer and FA core complex in mai...

Research Associate on the structural biology of bacterial secretion systems at Imperial College London (South Kensington Campus, London, UK). This is a postdoctoral research opening in the Department of Infectious Disease , working with Prof Harry Low and the Low Lab on the molecular mechanism of bacterial secretion systems, including the Tad and Type 4 pilus systems. The project is strongly focused on structural biology , cryo-electron microscopy (SPA, in-situ SPA, tomography), TIRF microscopy ...

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

PhD opportunity at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom on mTORC2 activation , AKT signaling , and related biochemistry , cancer biology , and molecular biology questions. The project focuses on how mTORC2 integrates activating inputs to control anabolism, survival, and cytoskeletal remodelling, with emphasis on positive feedback loops and upstream activation mechanisms. The student will help elucidate natural mechanisms of mTORC2 activation a...

PhD opportunity at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom on structural and cellular approaches to understand microtubule motors . This project sits at the intersection of cell biology , molecular biology , and structural biology , with a strong focus on microtubule motors such as dynein and kinesin . The research asks how motors are linked to cargos and coordinated to deliver organelles, RNAs, and proteins to the correct destination, especially...