PhD in Chromosome Biorientation and Kinetochore-Microtubule Interactions at the University of Dundee University of Dundee in United Kingdom

PhD opportunity in pathological protein assembly in neurodegenerative diseases at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom . The project is centered on the molecular pathology of neurodegeneration, with a focus on amyloid filament formation by disease-associated proteins such as TDP-43 , annexin A11 , and TAF15 . Two PhD project directions are described. One aims to reproduce pathological protein filament structures in vitro using protein biochemist...

PhD opportunity at the University of Dundee in the Faculty of Life Sciences on the project EASTBIO - Uncovering the non-canonical proteolytic activity of Deubiquitinating enzymes . This discovery-driven PhD sits at the interface of biochemistry , structural biology , cell biology , biophysics , and proteomics . The project focuses on ubiquitin-deconjugating enzymes (DUBs), especially the USP family, and their newly identified non-canonical “cleave-to-modify” activity. The research aims to define...

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

Funded PhD project at The Francis Crick Institute in London, United Kingdom, with Dr Frank Uhlmann and the Chromosome Segregation Laboratory. The project, Chromosome Organisation by Dynamic Cohesin Complexes , focuses on chromosome organisation , cohesin , chromatin loops , topologically associating domains , and the broader mechanisms of genome organisation and chromosome segregation . The lab studies how Structural Maintenance of Chromosome (SMC) complexes support sister chromatid cohesion, ch...

PhD opportunity at the University of East Anglia in the School of Biological Sciences on understanding the evolution of calcium signal decoding mechanisms in plants . The project is supervised by Dr Ben Miller and focuses on how plants use calcium signalling to respond to environmental stimuli and stresses, with a particular emphasis on the liverwort Marchantia polymorpha . This research combines molecular genetics , cell biology , and biochemistry to dissect calcium signalling and decoding mech...