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University of Southampton

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PhD in Gut Microbiome, Psychiatric Drug Interactions and Mental Health Resilience University of Southampton in United Kingdom

Degree Level

PhD

Field of study

Molecular Biology

Funding

The project is competition funded. Specific stipend and tuition-fee details are not stated in the provided content.

Deadline

Dec 18, 2026

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Country

United Kingdom

University

University of Southampton

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Keywords

Molecular Biology
Chemistry
Microbiology
Biology
Neuropsychology
Clinical Psychology
Chemical Biology
Medical Science
Pharmacy
Gut Microbiota
Omics
Mental Illness

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About this position

This interdisciplinary PhD will investigate how psychiatric drugs interact with the gut microbiome and how those interactions may influence mental health resilience and treatment response in defence personnel.

The project will move beyond observing changes in microbial communities to define drug–microbe interactions at cellular and molecular levels. You will study which gut microorganisms interact directly with psychiatric compounds, identify their molecular targets and investigate the pathways through which these interactions alter microbial function.

Your research will combine chemical synthesis of labelled psychiatric drugs with microbiome models, flow cytometry and metagenomic sequencing. Proteomics and transcriptomics will be used to uncover molecular mechanisms. Clinical psychiatry expertise will contribute patient samples, interpretation of results and assessment of their clinical relevance.

You will work across Biological Sciences and Chemistry with support from Clinical Sciences, gaining interdisciplinary experience in microbiology, microbiome science, chemical biology, molecular biology and multi-omics. The project aims to provide a mechanistic understanding of drug–microbiome interactions and their potential implications for personalised mental health treatment.

Funding details

The project is competition funded. Specific stipend and tuition-fee details are not stated in the provided content.

What's required

Applicants should hold a 2:1 honours degree. The project involves interdisciplinary training in microbiology, microbiome science, chemical biology, molecular biology and multi-omics, so relevant academic preparation and interest in these areas are expected.

How to apply

Review the project and full entry requirements on the University of Southampton webpage, then submit a PhD application through the university's postgraduate research application process before 18 December 2026.

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