PhD in Hidden RAS Conformations at the Membrane Medical Research Council (Cambridge) Laboratory of Molecular Biology in United Kingdom

PhD opportunity at the University of Dundee in the Faculty of Life Sciences on the project EASTBIO - Uncovering the non-canonical proteolytic activity of Deubiquitinating enzymes . This discovery-driven PhD sits at the interface of biochemistry , structural biology , cell biology , biophysics , and proteomics . The project focuses on ubiquitin-deconjugating enzymes (DUBs), especially the USP family, and their newly identified non-canonical “cleave-to-modify” activity. The research aims to define...

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

PhD opportunity at the University of Dundee in the area of cell biology , biochemistry , biophysics , genetics , and molecular biology . The project, supervised by Prof Tomo Tanaka , investigates how cells achieve correct chromosome biorientation during mitosis by regulating kinetochore-microtubule interactions . The work focuses on the outer kinetochore complexes Ndc80 and Dam1 , the role of Aurora B kinase in error correction, and how mechanical tension stabilises proper chromosome segregation...

PhD opportunity at King’s College London in the Randall Centre for Cell & Molecular Biophysics on molecular mechanisms of RNA–protein interactions and their dysregulation in human disease . This project focuses on how RNA-binding proteins (RBPs) recognize structured RNA elements, how their conformations are remodeled, and how post-translational modifications such as phosphorylation regulate translation and complex assembly. The research combines structural biology , biophysics , RNA biochemistry...

PhD opportunity at Durham University in AI protein design, structural biology, plant immunity, and bioinformatics . This fully funded four-year Gatsby Sainsbury PhD project in the Department of Biosciences and the Centre for Programmable Biological Matter (CPBM) aims to design synthetic plant immune receptors from first principles. The project combines generative protein design (including RFdiffusion, ProteinMPNN, and BindCraft), structural bioinformatics, structural biology, and plant functiona...