Publisher
source

Amsterdam UMC

Just Landed

PhD in Spatial Proteomics and Cell-Type Vulnerability in Frontotemporal Dementia Amsterdam UMC in Netherlands

Degree Level

PhD

Field of study

Biochemistry

Funding

This is a salaried, fixed-term PhD employment position with Amsterdam UMC Research BV. The initial contract is for 12 months, with the intention to extend to a total of four years under the Guideline PhD contract. The salary is €3,217–€4,077 gross for full-time employment, depending on experience, plus an 8.3% end-of-year bonus. Benefits include holiday hours, full public-transport reimbursement, mileage allowance of €0.21 per kilometer up to specified limits, a bicycle scheme, and pension accru

Deadline

Nov 15, 2026

Country flag

Country

Netherlands

University

Amsterdam UMC

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Keywords

Biochemistry
Molecular Biology
Biology
Neuropsychology
Medical Science
Neurodegenerative Disease

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About this position

Amsterdam UMC is offering a PhD position in spatial proteomics and neurodegeneration, focused on understanding how cell-type vulnerability and resilience contribute to frontotemporal dementia (FTD).

The PhD researcher will design and perform proteomics studies using human postmortem FTD brain tissue and patient-derived iPSC neuronal cultures. The project will employ innovative single-cell, spatial proteomics, and other omics technologies to investigate molecular and cellular dysfunction, cell-specific vulnerability, and cellular crosstalk in the human brain. Researchers will also contribute to data integration, scientific publications, regulatory-ready data packages, student supervision, and presentations at meetings and conferences.

The project is part of the NWO-funded Adore/KIC-LTP consortium and the broader Adore initiative, bringing together expertise from Amsterdam UMC, the Cancer Center Amsterdam, the Center for Neurogenomics & Cognitive Research at Vrije Universiteit Amsterdam, and the Alzheimer Center Amsterdam UMC. The position is embedded in the single-cell proteomics unit and involves collaboration with Dr. Claudia Ctortecka.

Applicants should hold a master's degree in neuroscience, biomolecular science, or biochemistry, with practical molecular and cellular research experience. Programming and data-analysis skills in Python and R are expected; experience with omics datasets is advantageous. Strong English communication, organization, accuracy, teamwork, creativity, independence, and initiative are also sought.

The appointment is initially for 12 months, with the intention to extend to four years. The salary is €3,217–€4,077 gross per month for full-time employment, depending on experience, plus an 8.3% end-of-year bonus and additional employment benefits. The application deadline is 15 November 2026, although applications are reviewed continuously and the vacancy may close early.

Funding details

This is a salaried, fixed-term PhD employment position with Amsterdam UMC Research BV. The initial contract is for 12 months, with the intention to extend to a total of four years under the Guideline PhD contract. The salary is €3,217–€4,077 gross for full-time employment, depending on experience, plus an 8.3% end-of-year bonus. Benefits include holiday hours, full public-transport reimbursement, mileage allowance of €0.21 per kilometer up to specified limits, a bicycle scheme, and pension accru

What's required

A master's degree in neuroscience, biomolecular science, or biochemistry is required. Applicants should have proven expertise and skills in molecular and cellular work, typically gained through an internship, experience with programming and data analysis in Python and R, and strong written and verbal communication skills in English. Experience with omics datasets is an advantage. The role also requires excellent organizational and management skills, accuracy, teamwork in an interdisciplinary environment, creativity, independence, and initiative.

How to apply

Apply through the vacancy page by clicking “Apply now.” Applications are handled continuously during the publication period and may close early if the position is filled. Questions about the position can be directed to Claudia Ctortecka at [email protected].

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