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Alexey Zaikin

1 year ago

PhD in Synthetic Biology and Cancer Immunotherapy: Engineering Feedback Control in CAR-T Cells University College London in United Kingdom

Degree Level

PhD

Field of study

Molecular Biology

Funding

The position is fully funded for 4 years through the UCL EPSRC Landscape Award (UELA). Funding includes full tuition fees (Home or International rate), a maintenance stipend of at least £23,466 per year (2026/27, rising annually), and a Research Training Support Grant (RTSG) for project costs, conferences, and travel. International students receive an additional award to cover the fee difference. Part-time study is available for Home students only, with funding adjusted pro-rata.

Deadline

Expired

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Country

United Kingdom

University

University College London

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Keywords

Molecular Biology
Immunotherapy
Biomedical Engineering
Biology
Health Science
Systems Biology
Synthetic Biology
Biochemical Engineering
Mathematical Biology
Bioprocessing
Cancer Therapy
Cell Culture Techniques

About this position

A fully funded PhD position is available at University College London (UCL) in the field of synthetic biology and cancer immunotherapy, focusing on engineering feedback control loops into CAR-T cell therapeutics. The project aims to address key challenges in CAR-T therapy, such as severe side effects and manufacturing variability, by designing artificial genetic circuits that enable mammalian cells to sense their population density and self-regulate their activity. This innovative approach could significantly improve the safety and reliability of CAR-T treatments for blood cancers. The successful candidate will join a multidisciplinary team in the Departments of Biochemical Engineering and Mathematics, working under the supervision of Dr Darren Nesbeth and Professor Alexey Zaikin. Training will include molecular cloning, mammalian cell culture, flow cytometry, genetic circuit design, and integration of experimental work with mathematical modeling. The project offers comprehensive mentorship and skills development relevant to both academia and the biotech industry. Applicants should have a strong background in life sciences, bioengineering, or biotechnology, with curiosity and enthusiasm for interdisciplinary research. The position is funded through the UCL EPSRC Landscape Award (UELA), covering full tuition, a competitive stipend, and research support for four years. Both Home and International students are eligible, though international places are limited. The application deadline is 13:00 UK time on 5 January 2026. Interested candidates should apply via the UELA online portal, ensuring all parts of the application and references are submitted by the deadline. For more details, visit the project and UELA webpages.

Funding details

The position is fully funded for 4 years through the UCL EPSRC Landscape Award (UELA). Funding includes full tuition fees (Home or International rate), a maintenance stipend of at least £23,466 per year (2026/27, rising annually), and a Research Training Support Grant (RTSG) for project costs, conferences, and travel. International students receive an additional award to cover the fee difference. Part-time study is available for Home students only, with funding adjusted pro-rata.

What's required

Applicants should have a strong foundation in life sciences, bioengineering, biotechnology, or related disciplines. Prior experience in molecular biology or mammalian cell culture is advantageous but not essential. Curiosity, creativity, problem-solving ability, enthusiasm for interdisciplinary collaboration, and strong communication skills are highly valued. Candidates must meet UCL's academic entry requirements and any additional departmental requirements. Both Home and International students are eligible, but international places are limited and highly competitive. English language proficiency as per UCL requirements is necessary.

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