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MRC Laboratory of Molecular Biology

PhD in the life cycle of ecDNA, replication stress, and reintegration Medical Research Council Laboratory of Molecular Biology in United Kingdom

Degree Level

PhD

Field of study

Molecular Biology

Funding

Competition funded PhD project. Funding details beyond this are not specified in the post.

Deadline

Dec 8, 2026

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Country

United Kingdom

University

MRC Laboratory of Molecular Biology

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Keywords

Molecular Biology
Cancer Biology
Biology
Mutagenesis
Medical Science
Dna Replication
Genomic

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About this position

PhD project: The life cycle of ecDNA at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom.

This project focuses on ecDNA (extrachromosomal DNA) in cancer, with emphasis on DNA replication, mutagenesis, replication stress, genomics, and molecular biology. The lab is interested in how ecDNA circles replicate, how stalled forks are rescued, and how ecDNA can reintegrate into the host genome to form homogenously staining regions (HSRs). The work also connects to synthetic genomics through the SynHG project and the integration of episomal intermediates.

The project will use established ecDNA-containing cancer cell line models together with synthetic ecDNA constructs. Methods include CRISPR-based genetic perturbation and high-resolution replication mapping to dissect the molecular mechanisms that sustain ecDNA replication and to study pathways leading to reintegration.

This is a competition funded PhD project and is listed as open to students worldwide. The post does not specify a stipend amount, tuition coverage, or language-test waiver. No separate scholarship programme name is given.

How to apply: Register your interest on the FindAPhD page. The university will contact applicants directly after enquiry submission.

Deadline: 2026-12-08.

Funding details

Competition funded PhD project. Funding details beyond this are not specified in the post.

What's required

Applicants should be interested in cancer biology, DNA replication, genomics, and molecular biology. The project uses established ecDNA-containing cancer cell line models, synthetic ecDNA constructs, CRISPR-based genetic perturbation, and high-resolution replication mapping, so relevant wet-lab and genome biology skills would be advantageous. The listing is for students worldwide; no specific degree class, GPA, or language-test requirement is stated in the post.

How to apply

Register your interest through the FindAPhD listing. The university will respond directly after you submit the enquiry form with your contact details.

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