PhD in Understanding Human Sulfatases Involved in Heparan Sulfate Degradation University of St Andrews in United Kingdom

PhD opportunity in Structure-Function Analysis of Stress Signaling at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with supervision by Dr A Bertolotti. The lab studies stress signaling and the integrated stress response (ISR), with a strong focus on how cells protect themselves from misfolded proteins and how these pathways may be harnessed to improve resilience in disease. The project is especially relevant to neurodegenerative diseases such as Alzheimer’s disease,...

PhD opportunity at The Francis Crick Institute, London, United Kingdom in structural biology, virology, biochemistry, biophysics, and molecular biology . This funded PhD project, supervised by Dr I Taylor , focuses on the ZAP antiviral response and how the proteins ZAP, KHNYN, and Trim25 assemble into molecular complexes that recognize viral RNA and trigger RNA degradation. The project aims to uncover the structure and mechanism of this antiviral system using protein purification, RNA-binding as...

PhD opportunity at the University of Bath in peptide design, TFEB activation, autophagy, lysosome biology, neurodegeneration, biochemistry, biophysics, cell biology, molecular biology, structural biology, and neuroscience . This project is part of the GW4 BioMed3 MRC Doctoral Landscape Programme (DLP) , which offers up to 17 studentships for entry in September 2026 . The project asks whether designed peptides can directly activate TFEB , a key regulator of cellular waste clearance, to improve re...

Funded PhD project at the University of Bristol in the School of Biochemistry and Biomedical Sciences on beta-lactam antibiotic targets for improving melioidosis treatment. The project focuses on the soil-borne pathogen Burkholderia pseudomallei , a major cause of melioidosis, and aims to understand how clinically important beta-lactams interact with bacterial cell-wall enzymes such as penicillin-binding proteins (PBPs) and L,D transpeptidases (LDTs) . The work combines recombinant protein expre...

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...