PhD: Mechanism of Induction of Cancer Stem Cells During Metastasis (CSC-funded or Self-funded) University of Bristol in United Kingdom

Funded PhD opportunity at the University of Warwick in the United Kingdom on sporulation biology of a honey-bee pathogen . This project focuses on Paenibacillus larvae , the bacterium that causes American Foul Brood (AFB) in honeybee larvae. AFB is a serious notifiable disease in many countries, including the UK, and has major consequences for beekeeping and pollinator health. The research aims to build a deeper molecular understanding of how this spore-forming pathogen completes its life cycle ...

PhD opportunity in Haematological Malignancies and Haematopoietic Stem Cell Biology at the University of Cambridge , Cambridge Stem Cell Institute, with Dr Adam Wilkinson and the Wilkinson Group. The project focuses on haematopoietic stem cells (HSCs) , blood cancers , cell biology , and developmental biology . Research themes include the molecular regulation of HSC self-renewal and lineage commitment, how HSC dysfunction can initiate blood cancer, and the development of novel HSC-based therapie...

PhD opportunity in epithelial cell fate and tumour development at the University of Cambridge , Cambridge Stem Cell Institute, in the Khaled Group led by Professor Walid Khaled . This project focuses on tumour initiation , cancer prevention , lineage tracing , epithelial cell fate , and related questions in cancer biology , cell biology , developmental biology , and stem cell biology . The lab studies early cellular and molecular changes associated with tumour development, with translational aim...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on cerebral small vessel disease (cSVD) , with a focus on identifying shared mechanisms and therapeutic targets across genetic and sporadic disease forms. The project will use patient-derived induced pluripotent stem cell (iPSC) models to study vascular cell phenotypes in the neurovascular unit. The research combines cellular biology , molecular biology , functional assays , and transcriptomics/omics to un...

PhD opportunity at The Francis Crick Institute in London, United Kingdom on Determinants of Clonal Fitness in SF3B1-Mutant Clonal Haematopoiesis . This funded PhD project with Dominique Bonnet explores how SF3B1 mutations drive clonal fitness in clonal haematopoiesis , with a strong focus on stem cell biology , RNA splicing , epigenetics , and the ageing bone marrow niche . The project aims to define the molecular mechanisms that give mutant haematopoietic stem cells a competitive advantage, und...