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Lars Jeuken

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PhD position: Bacterial packaging of biocatalytic nanofactories Leiden University in Netherlands

Degree Level

PhD

Field of study

Biochemistry

Funding

Salary between €3204 and €4051 gross per month for a full-time PhD appointment (38 hours); employment contract for one year with a view to permanent employment; holiday allowance (8%), end-of-year bonus (8.3%), pension scheme, and public transport commuting reimbursement.

Deadline

Nov 27, 2026

Country flag

Country

Netherlands

University

Leiden University

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Keywords

Biochemistry
Chemistry
Biotechnology
Biology
Biocatalysis
Enzyme Engineering
Protein Expression

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About this position

This PhD project at Leiden University explores a new approach to building biocatalytic nanofactories by packaging biocatalysts inside lipid vesicles during bacterial expression. The work sits at the intersection of synthetic cells, biotechnology, and enzyme engineering, with the aim of creating ready-to-use liposome-encapsulated systems for cascade reactions.

You will work on optimising and applying a technology that confines biocatalysts in vesicles while they are produced in bacteria, a strategy intended to improve yields and generate functional nanoreactors. The project is especially relevant if you are interested in the expression, characterisation, and engineering of biocatalysts, as well as the structure-function relationships that govern enzyme performance.

The position is embedded in the Jeuken lab, led by Prof. Lars Jeuken, within the Macromolecular Biochemistry group at the Leiden Institute of Chemistry. You will join a shared biochemical lab headed by multiple group leaders and a collaborative, transparent, and inclusive research environment. The wider faculty context includes strong links across the Faculty of Science and a research setting at Leiden’s Bio Science Park, with access to advanced lab infrastructure and an international network of research groups.

Funding details

Salary between €3204 and €4051 gross per month for a full-time PhD appointment (38 hours); employment contract for one year with a view to permanent employment; holiday allowance (8%), end-of-year bonus (8.3%), pension scheme, and public transport commuting reimbursement.

What's required

A Master’s degree in Life Sciences and Technology, Biochemistry, Biotechnology, or a related discipline is required. Candidates should have experience in cloning, expression, purification and characterisation of biocatalysts, and preferably also in the preparation and analysis of lipid vesicles. Strong interest in enzyme structure-function relationships, excellent technical experimental and analytical skills, ability to work independently, good scientific English, excellent communication skills, and comfort working in a collaborative environment are expected. Applicants must live and be officially registered as residents in the Netherlands or be willing to relocate when the position starts.

How to apply

Apply via the application button on the AcademicTransfer page. Include a motivation letter, an extensive CV, the courses and grades from your Master’s studies, and contact details for at least two references.

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Professors

Prof. at Leiden University

University Name
Country flag

Netherlands

Research Interests

Biochemical Engineering

Polymer Chemistry

Membrane Biology

Liposome Technology

Enzyme Engineering