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Karolinska Institutet
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PhD Position in Decoding Bone Metastasis in Neuroblastoma Karolinska Institutet in Sweden
Degree Level
PhD
Field of study
Immunology
Funding
The position is a full-time doctoral studentship for a maximum of four years with contractual monthly salary under Karolinska Institutet's doctoral-student salary scale. Employees receive access to a modern gym and medical-care reimbursements.
Deadline
Dec 9, 2026
Country
Sweden
University
Karolinska Institutet
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About this position
Karolinska Institutet is offering a four-year doctoral project in the Baryawno laboratory at BioClinicum in Stockholm, affiliated with the Division of Pediatric Oncology and Pediatric Surgery in the Department of Women’s and Children’s Health.
The project, “Decoding the metastatic cascade to bone,” addresses high-risk neuroblastoma, an embryonal tumour in which bone marrow metastases are common and relapse in bone is frequently fatal. The research will investigate which tumour clones seed bone, how the bone niche shapes their fate, and which niche-dependent vulnerabilities could be therapeutically targeted.
This is an in vivo-intensive cancer biology project. The doctoral student will use mouse models of metastasis, cell-barcode lineage tracing, single-cell RNA sequencing and in vivo CRISPR activation and loss-of-function screens. Work will also include analysis of pre-metastatic niche remodelling, bone-marrow sampling from xenograft-bearing mice, and functional validation of metastasis-driving clones and genes.
The student will develop practical expertise in subcutaneous, orthotopic and intracardiac tumour-cell injection, minor surgery, bioluminescence imaging, organoid and tumoroid culture, CRISPR screening, single-cell and spatial transcriptomics, flow cytometry and associated bioinformatics. The project is designed to support several first-author publications.
The student will be mentored by Dr Ninib Baryawno and work with co-supervisors Dr Kasper Karlsson, Professor Daniel Bexell, Dr Jakob Stenman and Dr Thale Olsen. The Baryawno laboratory is an expanding research environment combining basic, translational and clinical approaches in neuroblastoma, with expertise in molecular biology, immunology, bioinformatics, single-cell technologies and preclinical models.
The doctoral student will join Karolinska Institutet, a leading medical university with an international research environment and opportunities for collaboration and exchange.
Funding details
The position is a full-time doctoral studentship for a maximum of four years with contractual monthly salary under Karolinska Institutet's doctoral-student salary scale. Employees receive access to a modern gym and medical-care reimbursements.
What's required
Applicants must have a second-cycle/advanced/master qualification, or at least 240 credits including 60 credits at advanced/master level, or substantially equivalent knowledge. English proficiency equivalent to Swedish upper-secondary English B/English 6 is required. Applicants must be highly motivated, able and willing to learn and perform animal procedures in mouse cancer models. Good English communication skills and the ability to work collaboratively are required. Hands-on experience with preclinical in vivo mouse models of cancer is a merit; a laboratory animal science course such as FELASA is a strong merit. Experience in paediatric or neuronal cancers, neuroblastoma, molecular and cell biology, organoid/tumoroid culture, CRISPR screening, single-cell RNA-seq, spatial transcriptomics, flow cytometry or bioinformatics is advantageous but not essential.
How to apply
Submit the application and supporting documents through the Varbi recruitment system using the Login and apply button. Include a personal letter, CV, degree projects and publications if applicable, documentation of relevant skills, and documents certifying general and specific doctoral eligibility. Applications may be written in English or Swedish.
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