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Hannes Link

3 months ago

PhD Position in Genome Engineering and Host-Pathogen Interactions University of Tübingen in Germany

Degree Level

PhD

Field of study

Immunology

Funding

Available

Country flag

Country

Germany

University

University of Tübingen

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Keywords

Immunology
Microbiology
Biology
Mass Spectrometry
Medical Science
Pathogen Biology
Host-pathogen Interaction
Bacterial Genetics
Genome Engineering
Metabolomic

About this position

PhD position at the Cluster of Excellence Controlling Microbes to Fight Infections (CMFI), University of Tübingen, in the Link Lab.

The project focuses on genome engineering, host-pathogen interactions, microbiology, and immunology. The successful candidate will use CRISPR interference (CRISPRi) libraries in E. coli and S. aureus to identify bacterial genes involved in immune evasion, then combine high-throughput immune assays, metabolomic profiling, and LC-MS/MS analysis to discover targets that increase immune visibility of pathogenic bacteria.

This is a collaborative interdisciplinary project with the Mager Lab (immunology), including dendritic cell reporter assays and analysis of bacterial surface structures such as LPS and wall teichoic acids. The position is initially limited to three years and is to be filled as soon as possible.

Eligibility highlights: a Masters degree in biotechnology, microbiology, molecular biology, or a related field; background in microbial genetics, molecular biology, or infection biology; and strong English communication skills. Experience with CRISPR methods, cloning, bacterial genetics, metabolomics, mass spectrometry, Python, or R is advantageous.

How to apply: email one PDF containing a cover letter, CV, and relevant certificates to [email protected]. Applications are reviewed from 2026-04-01 until the position is filled.

Funding details

Available

What's required

Applicants should hold a Masters degree in biotechnology, microbiology, molecular biology, or a related field. A background in microbial genetics, molecular biology, or infection biology is required. Experience with CRISPR-based methods, molecular cloning, or bacterial genetics is a plus, as is experience with metabolomics, mass spectrometry, or data analysis using Python or R. Excellent written and spoken English skills and strong motivation to work at the interface of microbiology and immunology are expected.

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Professors

Professor

University Name
Country flag

Germany

Research Interests

Microbiology

Immunology

Biology

Metabolomic

Metabolic Engineering