PhD Position in Nanomedicine for Targeted Bone Cancer Treatment (Materials Chemistry/Nanoscience) Sorbonne Université in France

A fully funded PhD position is available in nanomedicine research, focusing on the development of gold nanoparticles decorated with POM-bisphosphonates for targeted bone cancer treatment. The project is a collaboration between Sorbonne Université (Paris) and Université de Reims Champagne-Ardenne, supervised by Anne Vallée (LRS, Sorbonne Université) and Frédéric Velard (UR BIOS, Université de Reims).

The research aims to address the challenge of bone metastases in advanced cancers by creating a multi-therapeutic nanoplatform. The platform leverages bisphosphonates' affinity for hydroxyapatite to enable bone-targeted drug delivery, combines photothermal and photodynamic therapy under near-infrared irradiation, and incorporates osteoclast inhibition with mild photothermia-driven bone regeneration.

Key scientific approaches include the green synthesis and characterization of gold nanomaterials (AuNS, 50–100 nm) using colloidal methods, functionalized with POM-bisphosphonates. Characterization techniques include UV-vis, DLS, TEM/HRTEM, XPS, and ICP. Phototherapeutic properties are evaluated via infrared imaging and chemical trapping of reactive oxygen species. Biological evaluations involve in vitro assays on osteosarcoma cell lines and human skeletal stem cells to assess bone affinity, anti-resorptive activity, and osteogenic differentiation.

Applicants should have a Master 2 in materials chemistry, inorganic chemistry, or nanosciences, with skills in colloidal synthesis and material characterization. Fluency in English and/or French is required, and a strong interest in biology and nanomedicine is essential. The position is funded for 3 years under the INLIFE program, starting Autumn 2026. To apply, send your CV and academic references to [email protected].

This opportunity is ideal for candidates passionate about interdisciplinary research in nanomedicine, materials science, and cancer therapy. The project offers access to advanced laboratories and collaborative supervision from leading researchers in France.