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Delft University of Technology

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PhD Position in Scalable Lipid Nanoparticle Purification Technologies Delft University of Technology in Netherlands

Degree Level

PhD

Field of study

Biomedical Engineering

Funding

Doctoral employment for 4 years in principle, split into an initial 1.5-year contract and a subsequent 2.5-year contract subject to performance and go/no-go assessment. Salary ranges from €3059 to €3881 gross per month based on full-time employment (38 hours/week), plus 8% holiday allowance and an 8.3% end-of-year bonus. Health insurance discounts and a monthly work costs contribution are offered.

Deadline

Oct 6, 2026

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Country

Netherlands

University

Delft University of Technology

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Keywords

Biomedical Engineering
Mechanical Engineering
Chemical Engineering
Materials Science
Drug Delivery
Biology
Process Engineering
Nanomedicine
Biofiltration
Lipid Nanoparticles
Physics

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About this position

PhD opportunity at Delft University of Technology (TU Delft) in scalable lipid nanoparticle purification technologies, with a strong focus on chemical engineering, process engineering, computational fluid dynamics, filtration, and nanomedicine.

This PhD is part of the SPARC program (Scalable Personalized Nanotherapeutics for Cancer Treatment), which aims to improve cancer therapy through personalized nanomedicines, tumor-on-a-chip platforms, and advanced manufacturing technologies. The project is shared between the Precision Therapeutics group (Dr. Alina Rwei) and the Complex Fluid Processing group (Prof. Johan Padding) at TU Delft, with collaboration across an academic-industrial network including Merck KGaA and Johnson & Johnson.

The research topic is the purification of lipid-based drug delivery nanoparticles after manufacturing. You will investigate dilution, ultra-/diafiltration, membrane fouling, and tangential flow filtration, and design improved purification systems that reduce nanoparticle loss and increase throughput. The work combines CFD simulations, modeling of fouling build-up, novel flow geometry design, membrane material exploration, and experimental verification of alternative membranes and modular purification components.

Eligibility highlights: MSc or equivalent in Chemical Engineering, Process Engineering, Mechanical Engineering, Nanotechnology, or a related field; strong analytical mindset; ability to work across computational and experimental domains; excellent English communication skills; experience with CFD or pharmaceutical downstream processing is a plus.

Funding and employment: This is a paid PhD employment position at TU Delft for 4 years in principle. Salary ranges from €3059 to €3881 gross per month (full-time, 38 hours/week), plus holiday allowance and end-of-year bonus. TU Delft also mentions health insurance discounts, a monthly work costs contribution, flexible work schedules, and relocation support for moving to the Netherlands.

Application deadline: 6 October 2026. Apply online with a CV, Bachelor’s and Master’s transcripts, and a motivation cover letter.

Funding details

Doctoral employment for 4 years in principle, split into an initial 1.5-year contract and a subsequent 2.5-year contract subject to performance and go/no-go assessment. Salary ranges from €3059 to €3881 gross per month based on full-time employment (38 hours/week), plus 8% holiday allowance and an 8.3% end-of-year bonus. Health insurance discounts and a monthly work costs contribution are offered.

What's required

MSc or equivalent in Chemical Engineering, Process Engineering, Mechanical Engineering, Nanotechnology or a related field. Applicants should have an analytical mindset and be able to work across computational and experimental domains. Excellent communication skills in English are required, and experience with computational fluid dynamics simulations or pharmaceutical downstream processes is a plus. English proficiency is required for PhD study at TU Delft.

How to apply

Apply online via the application button by 6 October 2026. Upload a detailed CV, Bachelor’s and Master’s transcripts, and a cover letter outlining your motivation and key experience. Do not apply by email or post.

More information can be found here

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