Publisher
source

Meritxell Canals

10 months ago

PhD: Role of Plasma Membrane Deposition in the Adverse Effects of Fentanyl University of Nottingham in United Kingdom

Degree Level

PhD

Field of study

Cell Biology

Funding

Funded PhD Project (Students Worldwide)

Deadline

Expired

Country flag

Country

United Kingdom

University

University of Nottingham

Suggested positions

Publisher
source

University of Dundee

Country flag

United Kingdom

PhD opportunity at the University of Dundee in the Faculty of Life Sciences on the project EASTBIO - Uncovering the non-canonical proteolytic activity of Deubiquitinating enzymes . This discovery-driven PhD sits at the interface of biochemistry , structural biology , cell biology , biophysics , and proteomics . The project focuses on ubiquitin-deconjugating enzymes (DUBs), especially the USP family, and their newly identified non-canonical “cleave-to-modify” activity. The research aims to define...

Cell Biology
Biochemistry
Molecular Biology
+7 more

1 week ago

Publisher
source

Medical Research Council (Cambridge)

Country flag

United Kingdom

PhD opportunity: Golgi function in brain organoids at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, UK. This project investigates how the Golgi apparatus organizes membrane trafficking and how Golgi proteins contribute to tissue function and neurodevelopment. The research uses brain organoids derived from stem cells to model tissue formation in vitro, with a focus on the YIPF5 protein complex and related proteins implicated in microcephaly, epilepsy, and diabetes (ME...

Cell Biology
Biochemistry
Biology
+4 more

1 month ago

Publisher
source

Maj Institute of Pharmacology Polish Academy of Sciences

Country flag

Poland

Position: Assistant (post-doc) (F/M/X) at the Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, under the OPUS 22 call. This is a postdoctoral research opening in neurochemistry. The posting indicates a research appointment in the Department of Neurochemistry at the Institute of Pharmacology of the Polish Academy of Sciences, with the OPUS 22 project reference. Research area: neurochemistry, neuroscience, biochemistry, molecular biology, pharmacology, and relat...

Cell Biology
Pharmacology
Biochemistry
+7 more

2 weeks ago

Publisher
source

University of Cambridge

Country flag

United Kingdom

Department of Pathology, University of Cambridge is advertising a fully funded PhD studentship in the lab of Professor Heike Laman . The project investigates how ubiquitin regulates secretory trafficking in dopaminergic neurons , with a focus on how the E3 ubiquitin ligase subunit FBXO7 controls protein movement through the secretory pathway. The research uses human stem cell-derived neurons as a model system and combines live-cell imaging , RUSH assays , proteomics , and functional experiments....

Cell Biology
Molecular Biology
Chemistry
+5 more

1 month ago

Publisher
source

University of Birmingham

Country flag

United Kingdom

Fully funded competitive PhD studentship available in the team of Professor Aga Gambus at the University of Birmingham. The project focuses on regulation of p97 unfoldase in the context of DNA replication and ubiquitylation. The research is interdisciplinary and combines biochemistry, structural biology, and cell biology, making it a strong fit for candidates interested in DNA metabolism and protein regulation. The studentship is offered through the Midlands Integrative Biosciences Training Part...

Cell Biology
Biochemistry
Chemistry
+5 more

3 days ago

Keywords

Cell Biology
Pharmacology
Biochemistry
Chemistry
Biophysics
Biology
Membrane Biology
Neuropsychology
Medical Science
Harm Reduction
Adverse Effects
Opioid Use

About this position

Drug-related deaths in the UK have reached record highs, with opioid drugs such as fentanyl implicated in the majority of cases. Despite its widespread impact, the pharmacology of fentanyl and the mechanisms underlying its potent adverse effects remain poorly understood. Recent evidence suggests that fentanyl's ability to partition into cell membranes may play a critical role in its extreme potency and harmful effects compared to other opioids.

This fully funded PhD project at the University of Nottingham's School of Life Sciences offers the opportunity to investigate the pharmacology of fentanyl using a multidisciplinary approach that combines cell biology, pharmacology, and biophysical techniques. The successful candidate will explore how plasma membrane deposition influences fentanyl's pharmacological profile and will design strategies to mitigate its harm. The project will involve advanced methods such as single molecule microscopy, protein-lipid interaction studies, and neutron reflectometry, drawing on expertise from a collaborative supervisory team.

The supervisory team includes Professor Meritxell Canals (University of Nottingham), Dr. Dylan Owen, and Dr. Luke Clifton (University of Birmingham), whose research spans membrane biology, pharmacology, and biophysical analysis. The project is supported by the Medical Research Council (MRC) and provides a comprehensive studentship package: 4 years of funding covering stipend, tuition fees (home and international rates), laptop allowance, research training and support grant (£5,000 per annum), and travel allowance (£300 per annum).

Applicants should have or expect to obtain a first or upper second class undergraduate degree in a relevant discipline such as biology, biochemistry, pharmacology, neuroscience, or related fields. Applications are welcome from home, EU, and international candidates, though international recruitment is capped at 30% of the cohort due to funding stipulations. The application deadline is 12:00 pm GMT on January 9, 2026. For further details and to apply, visit the MRC AIM website. Project enquiries can be directed to Professor Meritxell Canals at [email protected].

This project is ideal for students interested in cutting-edge research at the intersection of cell biology, pharmacology, and biophysics, with the potential to contribute to harm reduction strategies for opioid drugs. References supporting the scientific background of the project are provided in the position listing.

Funding details

Funded PhD Project (Students Worldwide)

What's required

Applicants should hold or expect to obtain a first or upper second class undergraduate degree (or equivalent) in a relevant discipline such as biology, biochemistry, pharmacology, neuroscience, or related fields. International applicants are welcome, but recruitment is capped at 30% of the cohort. Strong interest in cell biology, pharmacology, and biophysical research is preferred. No specific language test requirements mentioned.

ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts and confirm requirements with the university.

Professors

Professor at School of Life Sciences

University Name
Country flag

United Kingdom

Research Interests

Pharmacology

Cell Biology

G Protein-coupled Receptor

Opioid Use

Allosteric Regulation