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Gustav Berggren

Just Landed

Posted Yesterday

PhD student in Chemistry – specializing in Molecular Biomimetics Uppsala University in Sweden

Degree Level

PhD

Field of study

Biochemistry

Funding

Available

Deadline

Dec 14, 2026

Country flag

Country

Sweden

University

Uppsala University

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Keywords

Biochemistry
Chemistry
Biophysics
Biology
Spectroscopy
Electrochemistry
Bioinorganic Chemistry
Epr
Kinetics Modeling
Metalloenzyme

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About this position

The doctoral project is based in the bioinorganic chemistry group within the molecular biomimetics program at the Department of Chemistry – Ångström, Uppsala University. The group is described as internationally recognized, highly visible, and located in a modern building at the Ångström Laboratory. The research environment is strongly collaborative, with cross-disciplinary interactions and cooperation with specialists at Uppsala University and other universities in Sweden and abroad.

The project focuses on hydrogenase enzymes, redox-active metalloenzymes that catalyze the conversion between protons and molecular hydrogen. The research is driven by recent findings suggesting that [FeFe] hydrogenases may not be fully reversible catalysts, but instead show an intrinsic bias toward hydrogen uptake or production. The project explores the idea that these enzymes may function as “metabolic rectifiers,” enabling unidirectional electron flow with minimal energy loss and supporting energy metabolism near thermodynamic limits.

The doctoral student will investigate the prevalence of unidirectional catalysis across hydrogenases from different ecological and phylogenetic contexts and help identify the molecular features that control catalytic directionality. The work includes the isolation and characterization of novel [FeFe] hydrogenases, detailed study of selected enzymes, and mechanistic analysis using electrochemistry and spectroscopy including EPR and FTIR. The student will also contribute to rational design and analysis of enzyme variants, kinetic modelling, and scientific publication writing. The role combines experimental enzymology with biophysical and mechanistic analysis in a research-active chemistry environment.

The position is a doctoral appointment with a main focus on research and completion of third-cycle courses, with teaching and other departmental duties possible to a limited extent.

Funding details

Available

What's required

To meet the entry requirements for doctoral studies, the applicant must have been awarded a second-cycle degree in biochemistry, biophysics, biotechnology, or equivalent, or have completed at least 240 higher-education credits with at least 60 credits at Master’s level including an independent project worth at least 15 credits, or have acquired essentially equivalent knowledge in Sweden or abroad. The degree does not need to be completed at application, but must be awarded no later than the admission decision. The candidate must have experience in protein production and isolation and very good oral and written proficiency in English. Preferred qualifications include an interest in experimental work and data analysis, good collaborative skills, drive, independence, and experience in spectroscopic studies of proteins, electrochemistry or kinetic studies, and working with hydrogenases or other metalloenzymes.

How to apply

Submit the application through the Varbi application portal using the provided application link. Make sure the application is submitted by 14 December 2026. Refer to the advert for the position reference UFV-PA 2026/3469.

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Professors

Prof. at Uppsala University

University Name
Country flag

Sweden

Research Interests

Biochemistry

Epr

Metalloenzyme

Biophysics

Chemistry