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Lund University

PhD student in Epigenetics and Chromatin Dynamics Lund University in Sweden

Degree Level

PhD

Field of study

Computer Science

Funding

Available

Deadline

Nov 13, 2026

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Country

Sweden

University

Lund University

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Keywords

Computer Science
Chemistry
Biomedical Engineering
Biology
Functional Genomics
Neuropsychology
Transposable Elements
Medical Science
Neurodevelopment
Nanopore Sequencing
Rna-seq
Epigenetic
Bioinformatic

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About this position

Laboratory of Epigenetics and Chromatin Dynamics at Lund University’s Department of Experimental Medical Science is recruiting a PhD student to join a project on how epigenetic mechanisms regulate repetitive and transposable genetic elements in human brain development and disease.

The research is led by Dr Christopher Douse and carried out in a group of 8 research-active members. The lab studies underexplored parts of the human genome often described as “genomic dark matter,” with a particular interest in how these regions contribute to neurobiology and neurological disease. The environment combines wet-lab and dry-lab research and emphasizes equity, collaboration, integrity, curiosity, and diversity.

The project focuses on three classes of repetitive elements with importance for brain function and disease: clustered protocadherin repeat genes, retrotransposons, and CGG microsatellite tandem repeats. The doctoral researcher will investigate the factors that bind and regulate these elements in neural lineages, and how they shape the epigenome, local transcriptional dynamics, and disease-related traits.

The work combines chromatin biochemistry with functional epigenomics in stem cell models of the human brain. The student will use advanced neural cellular models together with sequencing-based and biochemical approaches, including stem cell culture, neural progenitor systems, RNA sequencing, CUT&RUN/CUT&Tag, Oxford Nanopore sequencing, and co-immunoprecipitation or proximity labelling proteomics. The project also includes tailored bioinformatic analyses.

The position sits within Lund University’s Faculty of Medicine and offers a research setting focused on human molecular neurobiology, epigenomic regulation, and methodologically integrated training across experimental and computational approaches.

Funding details

Available

What's required

Applicants must have a second-cycle degree, completed course requirements of at least 240 higher education credits including at least 60 higher education credits at second-cycle level, or substantially equivalent knowledge acquired in Sweden or abroad, and must have the ability to benefit from doctoral studies. The position requires experience in functional (epi)genomics and/or chromatin biochemistry, experience with stem cell culture and differentiation models, a demonstrable interest in the repetitive genome, excellent knowledge of molecular biology and molecular genetics, excellent spoken and written English, good analytical skills, an independent and problem-solving approach, and an open, collaborative attitude. Highly organised and self-motivated candidates are viewed as an advantage, as are experience with long-read sequencing approaches, protein biochemistry, collaborative research, and a willingness to develop and learn during the doctoral studies.

How to apply

Submit a personal letter explaining your interest and fit for the position. Include a CV, degree certificates or equivalent, and any other supporting documents such as transcripts, referee details, or recommendation letters. Applications are reviewed on an ongoing basis during the application period.

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