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Uppsala University
5 days ago
Postdoctoral Fellow in Brain Tumor Evolution and Treatment Resistance Uppsala University in Sweden
Degree Level
Postdoc
Field of study
Biology
Funding
Temporary full-time postdoctoral employment for 2 years with the possibility of a 1-year extension; ERC-funded project RESET-DMG.
Deadline
Dec 4, 2026
Country
Sweden
University
Uppsala University
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About this position
A postdoctoral fellow position is open in the research group of Verónica Rendo at the Department of Immunology, Genetics and Pathology, Uppsala University. The project is centered on diffuse midline glioma (DMG), a malignant pediatric brain tumor, with a focus on how tumor cells respond to and become resistant to standard-of-care treatment and clinically relevant targeted therapies.
The fellow will join and help lead an arm of the ERC-funded RESET-DMG project, which seeks to map how DMG cells evolve resistance to radiation and multiple targeted therapies. The work combines patient-derived model systems with single-cell multiome approaches to trace tumor evolution, identify resistant cell populations, and characterize the transcriptional and epigenetic features associated with resistance.
The research involves building barcoded patient-derived DMG neurosphere models, applying treatment pressure, and tracking barcode dynamics to distinguish innate from acquired resistance. The project also includes generating and integrating single-cell RNA and ATAC data to uncover programs and chromatin states linked to resistant cells. The postdoc will work in a highly collaborative environment and will contribute to study design, manuscripts, conference presentations, and student supervision.
The position sits within a department that has strong research programs in cancer, genomics, neurobiology, and related translational areas, with links to several units at Uppsala University Hospital. More information is available from the department and the research group webpages.
Funding details
Temporary full-time postdoctoral employment for 2 years with the possibility of a 1-year extension; ERC-funded project RESET-DMG.
What's required
A PhD degree in cancer biology, molecular biology, genetics, neuroscience or a related field, or a foreign degree equivalent to a PhD in the same, must be obtained by the time of the employment decision. Priority is given to applicants who completed their degree no more than three years before the application deadline, although this may be extended for special circumstances. Applicants should have strong experimental expertise supported by peer-reviewed original research publications, hands-on mammalian cell culture experience including lentiviral transduction and patient-derived or stem-like models, documented experience analyzing single-cell and/or epigenomic data (scRNA-seq, scATAC-seq, multiome) in R and/or Python including quality control, integration and interpretation, strong experimental design and troubleshooting skills, good English communication skills, ability to work in an interdisciplinary environment, previous supervision experience, and evidence of collaborative skills. Additional merits include experience with cellular barcoding, lineage tracing, NGS library preparation, CRISPR screens, functional genomics, brain tumor/pediatric cancer/glioma models, drug resistance or tumor evolution, chromatin biology, transcription factor regulation, animal work in cancer, and a multidisciplinary wet-lab/computational background.
How to apply
Submit the application through the Varbi application portal using the provided link. Include a CV, cover letter, PhD diploma, publication list, and contact information for three references.
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